Ceftriaxone Injection 1g (Ceftriaxone Sodium Hydrate)

Adult administration

For adults and children over 12 years, administer 1–2g (potency) of ceftriaxone intravenously or intramuscularly once daily. For infections caused by severe or moderately susceptible pathogens, the dose can be increased up to 4g (potency) once daily.

Child administration

For neonates (within 14 days old), administer 20–50mg (potency) per kg of body weight once daily, not exceeding 50mg (potency) per kg of body weight. For infants and children (from 15 days to 12 years), administer based on body weight.

This drug should not be mixed or administered simultaneously with calcium-containing solutions or other drugs. Special caution should be taken as precipitation can occur when given simultaneously with calcium in newborns, potentially leading to serious side effects. Patients with allergies to this drug or its constituents, or those with a history of hypersensitivity to penicillins or cephalosporins, should not use this medication. This drug should not be administered to premature infants, newborns with jaundice or bilirubin conjugation issues, and also to newborns receiving calcium-containing solutions. Patients with a history of drug allergies or an allergic disposition should use this drug cautiously, and dosage adjustment is needed for patients with severely impaired renal function. Regular monitoring of liver and kidney function and blood status is important during clinical examination. Rarely, this drug can cause allergic reactions, diarrhea, skin rashes, liver function anomalies, and renal issues; any symptoms should be reported to medical personnel immediately. In particular, if severe allergic reactions or shock symptoms occur, administration should be stopped immediately and emergency treatment should be sought. The safety of this drug during pregnancy has not been entirely established, so it should be used cautiously in pregnant women under medical supervision, and breastfeeding women should also exercise caution. In children and the elderly, the risk of side effects may be higher due to bodily functions, requiring careful monitoring. This drug may cause dizziness when driving or operating machinery, requiring caution. Possible drug interactions may occur, so consultation with medical personnel is necessary when used with other medications, especially avoiding concurrent use with calcium, diuretics, and some antibiotics. When storing this drug, it should be used as soon as possible after preparation, and the prepared solution should be used within 6 hours at room temperature and 24 hours if refrigerated.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with high fever, blisters, skin peeling, oral/ocular mucosal pain, difficulty or shortness of breath, asthma attacks, cough with fever followed by respiratory distress, jaundice (yellowing of skin or eyes), extreme lethargy, sudden severe headache, lightning headache, seizures, altered consciousness, vision disturbances, paralysis, urination.

Mild side effects

Eosinophilia, leukopenia, thrombocytopenia, diarrhea, rash, increased liver enzymes, headache, dizziness, loose stools, nausea, vomiting, itching, hematuria, diabetes, phlebitis, injection site pain, fever, chills, increased serum creatinine, stomatitis, candidiasis, symptoms of vitamin K deficiency, symptoms of vitamin B deficiency, edema, ventricular extrasystole, sweating, flushing, palpitations, nosebleeds, hypotension, Clostridium difficile-associated diarrhea, pancreatitis,

This drug should be stored in a sealed container to prevent exposure to air or moisture and should be kept at temperatures between 1 and 30 degrees Celsius. Proper storage will ensure the safety and efficacy of the medication.

Appearance

A colorless, transparent vial filled with white to pale yellow crystalline powder.

Package unit

1g/vial X10