Hwamo Clej 375mg (Amoxicillin · Clavulanate Potassium)

Adult dose

Adults and children over 12 years or weighing over 40 kg: administer orally as amoxicillin/clavulanate potassium at a dosage of 250 mg/125 mg per dose, three times a day every 8 hours. In severe cases or respiratory infections, the dosage may be increased to 500 mg/125 mg per dose. Renal impairment patients: creatinine clearance above 30 mL/min requires no dosage adjustment. For creatinine clearance between 10 and 30 mL/min, administer once every 12 hours.

Child dose

Children under 12 years or weighing less than 40 kg: administer a reduced dosage similar to adults.

This medication is a beta-lactam antibiotic and should not be administered to patients with allergies to penicillin or cephalosporin medications. Particular caution is required for patients with histories of hypersensitivity reactions like anaphylaxis, Stevens-Johnson syndrome, or shock. It is advisable not to use this medication in patients with infectious mononucleosis or lymphocytic leukemia due to the risk of rash. Patients with liver dysfunction or a history of jaundice should be cautious as this medication may worsen liver function. Patients with moderate to severe renal impairment may experience increased drug concentration, necessitating adjustments in dosing intervals. Patients with allergies, those who cannot take medications orally, elderly patients, and those in poor general condition should be monitored closely. Gastrointestinal symptoms such as abdominal pain, diarrhea, and vomiting may occur; in severe cases, pseudomembranous colitis may develop, requiring immediate consultation with a physician if symptoms arise. Liver function tests may reveal elevated liver enzymes or symptoms of hepatitis and jaundice, which are rare but more frequently reported in men over 60 years of age. Skin rash, itching, and severe skin reactions may occur, and any symptoms should lead to discontinuation of the medication and following a doctor's recommendations. Blood dyscrasias such as leukopenia, thrombocytopenia, and hemolytic anemia have been reported rarely, so regular blood testing may be required. Central nervous system effects like anxiety, confusion, and seizures may occur, with a higher risk of seizures in patients with renal dysfunction. Rarely, acute renal failure or interstitial nephritis may occur, so kidney function should be monitored. Disruption of normal intestinal flora can lead to fungal infections such as candidiasis, necessitating immediate medical notification if symptoms arise. Bleeding tendencies due to vitamin K deficiency may occur; therefore, signs of bleeding should be monitored closely. This medication carries a risk for resistance development with prolonged use; hence, it is important to take it for the minimum duration necessary. Patients with hypersensitivity reactions to penicillin may experience severe allergic reactions; therefore, past medical history must be verified prior to administration. Anaphylactic shock may occur, so careful monitoring of the patient's condition is essential after administration. If severe diarrhea or abdominal cramping occurs, there is a possibility of pseudomembranous colitis, so medication should be stopped immediately and healthcare providers should be consulted. Administration during pregnancy, especially in the first trimester, should be avoided. During breastfeeding, unusual reactions such as diarrhea or skin rashes may occur in infants; therefore, caution is advised. Children are recommended to take it only if they are 12 years or older or weigh more than 40 kg, as there is limited experience in younger age groups. Elderly patients may exhibit adverse reactions more readily due to declining physiological functions, hence careful dose adjustments should be made while administering the medication. This medication may interact with other drugs, so it is crucial to inform healthcare providers of any other medications in use. In cases of overdose, gastrointestinal symptoms and renal function abnormalities may arise, and immediate healthcare evaluation is necessary.

Serious side effects

Hives, severe swelling (edema), chest tightness, breathing difficulties, cold sweat, pallor, high fever with severe rash, blisters, skin peeling, mucosal pain in the mouth/eyes, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, jaundice (yellowing of skin or eyes), extreme lethargy, sudden and severe headaches, lightning headaches, seizures, altered consciousness, visual disturbances, paralysis, urination abnormalities.

Mild side effects

• Diarrhea
• pseudomembranous colitis
• dyspepsia
• stomatitis
• gastritis
• glossitis
• nausea
• vomiting
• anorexia
• abdominal pain

This medication should be stored in a sealed container, protected from moisture, and placed in a dry location below 25 degrees Celsius to maintain its efficacy for a longer period.

Appearance

It is a white or almost white oval film-coated tablet.

Package unit

100 tablets (10 tablets/PTPX10)