Hukra 375 mg Tablets (Amoxicillin and Clavulanate Potassium (2:1))

Adult dose

Adults and children aged 12 years or over or weighing 40 kg or more should take 250 mg/125 mg of amoxicillin/clavulanate potassium 3 times daily every 8 hours orally. In severe cases and for respiratory infections, the dosage can be increased to 500 mg/125 mg per dose. For patients with renal impairment, the dosage should be adjusted according to creatinine clearance. - For patients with creatinine clearance of 30 mL/min or more: no dosage adjustment is necessary.

Child dose

Children under 12 years of age or weighing less than 40 kg are to receive a reduced dosage according to the same method as adults.

This medication is a beta-lactam antibiotic and should not be administered to patients with a history of hypersensitivity to penicillins, particularly those with a history of anaphylaxis or severe skin reactions. It is also advisable to avoid this medication in patients with infectious mononucleosis or lymphocytic leukemia, as they are at a higher risk of developing rashes. Patients who have previously experienced jaundice or hepatic dysfunction due to this medication or penicillins should also avoid administration. Patients with compromised liver function or moderate to severe renal impairment should use this medication carefully, regulating the dose and interval. Patients with a history of allergies, those who have difficulty swallowing, the elderly, and those in poor general health should also take caution. This medication can cause gastrointestinal symptoms such as diarrhea, vomiting, and abdominal pain, and in rare cases, serious adverse effects like colitis or acute pancreatitis may occur. Should any unusual symptoms appear, discontinue the medication and consult a physician immediately. Reports of hepatic dysfunction symptoms have also been noted, particularly in elderly patients or males, so liver function tests are necessary with prolonged use. Furthermore, severe allergic reactions such as skin rashes, urticaria, anaphylactic shock may occur infrequently; therefore, discontinue the use of the drug should any unusual symptoms manifest. Changes in blood tests, such as leukopenia, thrombocytopenia, or hemolytic anemia, have been reported rarely; regular blood tests are recommended. Central nervous system symptoms such as rare headaches, seizures, and confusion may also occur, and attention to renal function is necessary. This drug may interact with other medications, particularly anticoagulants or when combined with specific antibiotics or anti-inflammatory drugs. It may reduce the effectiveness of oral contraceptives, requiring additional contraceptive methods if necessary. The safety of this medication is not established in the early stages of pregnancy or during pregnancy; thus, it should only be used if absolutely necessary. During breastfeeding, it may cause diarrhea or allergic reactions in infants, and administration should be discontinued if adverse symptoms arise. Use in children, especially those under 12 years old or weighing less than 40 kg, is not recommended. In the elderly, the risk of adverse effects is higher due to diminished physiological function; therefore, careful observation of dosage and intervals is necessary. Regular tests for liver function, kidney function, and blood tests are required during the course of medication. In case of overdose, seek medical attention immediately for appropriate treatment. Store in a tightly sealed container, avoiding moisture, and keep in a cool place between 1 and 25 degrees Celsius. This storage will help maintain the drug's efficacy over time.

Serious side effects

Urticaria, severe edema, chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, severe rash with high fever, blistering, peeling skin, pain in oral/nasal mucosa, severe dermal reactions, dyspnea or difficulty breathing, asthma attacks, respiratory complications accompanied by cough and fever, yellowing of the skin or eyes (jaundice), severe lethargy, hepatic dysfunction (jaundice), sudden and severe headache.

Mild side effects

• Diarrhea
• colitis
• dyspepsia
• stomatitis
• gastritis
• glossitis
• black hairy tongue
• nausea
• vomiting
• loss of appetite

This medication should be stored in a tightly sealed container to prevent moisture and kept in a cool place between 1 and 25 degrees Celsius. Storing it this way will help maintain the drug's effect for a longer period.

Appearance

White or nearly white oval film-coated tablets

Package unit

100 tablets (10 tablets/PTPX10)