Terachams Tablet 0.5 mg (Varenicline Salicylate)

Adult dosage

1. Usual dosage in adults Patients should set a quit date and start taking this medicine 1 week before that date. Alternatively, they may start quitting between day 8 and day 35 after starting this medicine. This medicine should be taken after meals with plenty of water. The recommended dosage of this medicine is as follows: after dose titration over 1 week, administer 1 mg twice daily. Days 1 – 3 0.5 mg once daily Days 4 – 7 0.5 mg twice daily Day 8 – end of treatment 1 mg twice daily Patients who cannot tolerate the adverse reactions of this medicine may temporarily or permanently reduce the dose. This medicine is administered for 12 weeks. For patients who successfully quit smoking with the first 12 weeks of treatment, an additional 12 weeks of this medicine is recommended to increase the likelihood of long-term abstinence. For patients who cannot or do not wish to stop smoking abruptly, consider gradually reducing smoking while taking this medicine. Within the first 4 weeks after starting this medicine, reduce smoking by 50% compared with before treatment; reduce it by a further 50% within the following 4 weeks, and continue to reduce smoking so that complete abstinence is achieved by week 12. Administer this medicine for an additional 12 weeks for a total treatment duration of 24 weeks. Patients who fail to quit smoking with the first 12 weeks of treatment, or who resume smoking after treatment, should review the reasons for failure and try again. However, there are no data demonstrating the efficacy of an additional 12 weeks of treatment in patients who fail to quit smoking during the first 12 weeks of treatment or resume smoking after treatment. 2. Patients with renal impairment No dose adjustment is necessary in patients with mild (estimated creatinine clearance > 50 ml/min and ≤ 80 ml/min) to moderate (estimated creatinine clearance ≥ 30 ml/min and ≤ 50 ml/min) renal impairment. In patients with severe renal impairment (estimated creatinine clearance < 30 ml/min), the recommended starting dose of varenicline is 0.5 mg once daily. If needed, the maximum dose is 0.5 mg twice daily. In patients with end-stage renal disease receiving hemodialysis, a maximum dose of 0.5 mg once daily may be administered if well tolerated. 3. Elderly patients and patients with hepatic impairment No dose adjustment is necessary in patients with hepatic impairment. Because renal function is more likely to be reduced in elderly patients, use caution when selecting the dose; monitoring renal function may be useful.

Children's dosage

Use in patients under 18 years of age is not recommended.

This medication is used to assist in smoking cessation. During treatment, serious mental health issues such as depression, anxiety, aggression, hallucinations, and suicidal thoughts may occur, so caution is required. Patients with a history of psychiatric disorders must consult their doctor before use, and they should carefully monitor any changes in mental state during treatment. Pregnant or breastfeeding women should use this medication cautiously and consult with a doctor when necessary. While taking this medication, side effects such as nausea, headaches, insomnia, and abnormal dreams are common, and if these symptoms are severe or persistent, patients should consult a doctor. Patients with a history of seizures or those at risk for seizures should be adequately assessed for risks before taking this medication, and should immediately stop use and inform medical personnel if a seizure occurs. Activities requiring concentration, such as driving or operating machinery, should be approached with caution until the body's response to this medication is confirmed. Interactions with other drugs are minimal, but alcohol consumption may exacerbate side effects, so it is advisable to avoid or minimize alcohol while taking this medication. No specific antidote exists in cases of overdose, so appropriate treatment should be received according to symptoms, and dose adjustments may be necessary for patients with decreased kidney function. Store this medication out of the reach of children, and keep it in its original container to maintain quality.

• Suicidal thoughts
• suicidal behavior
• suicide
• changes in behavior or thoughts
• depression
• mania
• mood changes
• psychosis
• aggressive behavior
• hallucinations

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. It is best to maintain storage temperatures between 1 degree and 30 degrees Celsius room temperature.

Appearance

White or grayish-white, bilaterally convex, rectangular film-coated tablets

Package unit

11 tablets (11 tablets/BlisterX1)