Donepezil Tablets 23 mg (Donepezil Hydrochloride Monohydrate)

Adult dose

This medication should be taken once daily right before bedtime, regardless of food intake. The initial recommended dose of Donepezil Hydrochloride is 5 mg once daily. Normal status is reached after 15 days, and after administering 5 mg for 4 to 6 weeks, clinical response should be evaluated. Afterward, the dose can be increased to 10 mg, with caution regarding gastrointestinal adverse reactions. Patients should take 10 mg once daily for a minimum of 3 months.

This medication is primarily used for the treatment of symptoms of Alzheimer's type dementia and contains Donepezil Hydrochloride Monohydrate as its active ingredient. This medication should not be used in certain patients. For example, individuals with allergies to this medicine or its components, women who are pregnant or may become pregnant, and breastfeeding women should not take this medication. Additionally, individuals with a genetic disorder that inhibits lactose digestion should also avoid it. Patients with heart diseases or heart rhythm issues should use this medication with caution, as it can slow down heart rate or cause arrhythmias. Also, caution is needed for individuals with a history of peptic ulcers or those taking nonsteroidal anti-inflammatory drugs, as this medication may stimulate gastric acid secretion and exacerbate gastrointestinal problems. Patients with a history of asthma or obstructive pulmonary diseases should be cautious, as their symptoms may worsen when using this medication. Patients with extrapyramidal disorders like Parkinson's disease should also use this medication with care, as their symptoms may worsen. This medication contains the dye Yellow 4, so individuals allergic to this substance should be cautious when taking it. While taking this medication, various adverse reactions may occur. Typical issues include cardiac-related problems (bradycardia, heart block, myocardial infarction, etc.), gastrointestinal issues (peptic ulcer, gastrointestinal bleeding), liver dysfunction, neurological issues (seizures, cerebral hemorrhage), movement disorders, respiratory difficulties, acute pancreatitis, and renal failure. Mild symptoms such as nausea, vomiting, diarrhea, reduced appetite, dizziness, insomnia, headache, and fatigue may also frequently occur. These symptoms are usually temporary and can improve with dosage adjustments. This medication may affect cardiac conduction, so patients with a history of heart disease or prolonged QT interval should undergo ECG monitoring while taking it. Additionally, this medication can interact with various drugs. Caution is particularly needed when taken with medications that affect drug metabolism in the liver. The efficacy may change when used in conjunction with neuromuscular blockers, cholinergic drugs, and anticholinergic drugs, thus consultation with a healthcare professional is necessary. Women who are pregnant or breastfeeding are advised not to take this medication, and if it is absolutely necessary to take it, breastfeeding should be discontinued. Safety in children has not been established, so it is not used in pediatric patients. In case of overdose, severe symptoms such as nausea, vomiting, bradycardia, respiratory depression, and seizures may occur, and immediate medical attention is required. Antidotes such as atropine may be used in case of overdose. This medication should be kept out of reach of children and should not be transferred to other containers. Caution is needed during driving or operating machinery while taking this medication, as symptoms like fatigue, dizziness, and muscle cramps may occur. This medication is only used for dementia patients and has not been approved for other types of memory disorders. Treatment efficacy should be evaluated regularly, and discontinuation should be considered if there is no effect.

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, severe rashes with high fever, blisters, skin shedding, pain in mouth/eye mucosa, severe skin adverse reactions, shortness of breath or breathing difficulties, asthma attacks, respiratory abnormalities accompanied by cough and fever, breathing problems, yellowing of the skin or eyes (jaundice), extreme lethargy, liver abnormalities (jaundice), sudden and severe

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headache
• fatigue
• lethargy
• dizziness
• drowsiness
• insomnia

This medication should be stored in a tightly sealed container that is well-ventilated, and the storage temperature should be maintained at room temperature between 1 to 30 degrees Celsius. This storage method helps to preserve the effectiveness of the medication for a longer time.

Appearance

Red, biconvex, round film-coated tablets

Package unit

30 tablets/bottle