Tagrel 60mg (Ticagrelor)

Adult dose

Do not use this medicine in combination with other ADP receptor inhibitors (ticlopidine, clopidogrel, prasugrel). Acute coronary syndrome: Administer a single initial dose of 180mg, followed by 90mg twice daily. Treatment is recommended for 12 months unless discontinuation is clinically necessary. Patients taking this medicine should also receive a maintenance dose of aspirin (75 - 150mg), unless specifically contraindicated. In patients with acute coronary syndrome who have an increased risk of bleeding after percutaneous coronary intervention (PCI), monotherapy with this medicine (discontinuing aspirin) may be considered after 3 months of treatment with this medicine and aspirin. (See section 3. Administer with caution to the following patients.) Patients with a history of myocardial infarction (occurring at least 1 year previously) and at high risk of thrombotic cardiovascular events: Administer 60mg twice daily. Patients taking this medicine should also receive a maintenance dose of aspirin (75 - 150mg), unless specifically contraindicated. Patients who have been taking 90mg of this medicine or another ADP receptor inhibitor (ticlopidine, clopidogrel, prasugrel) during the first year after myocardial infarction may continue treatment with 60mg of this medicine. Treatment with this medicine may also be initiated in patients within 2 years after myocardial infarction or within 1 year after discontinuing a previous ADP receptor inhibitor (ticlopidine, clopidogrel, prasugrel). The safety and efficacy of this medicine were evaluated at 3 years of follow-up. Patients with type 2 diabetes who have undergone percutaneous coronary intervention (PCI) for coronary artery disease: Administer 60mg twice daily. Patients taking this medicine should also receive a maintenance dose of aspirin (75 - 150mg), unless specifically contraindicated. For patients with acute coronary syndrome, refer to the relevant dosage and administration instructions. Data on the safety and efficacy of this medicine for treatment lasting more than 3 years are limited. Patients with acute ischemic stroke or high-risk transient ischemic attack: Administer a single initial dose of 180mg, followed by 90mg twice daily for 30 days. Patients taking this medicine should also receive a maintenance dose of aspirin (75 - 100mg), unless specifically contraindicated. An initial loading dose of aspirin (300-325mg) is recommended in patients with acute ischemic stroke or high-risk transient ischemic attack. This medicine is administered orally and may be taken with or without food. For patients who have difficulty swallowing tablets, crush this medicine into a fine powder, disperse it in half a glass of water, and drink it immediately. Rinse the cup with another half glass of water and drink that as well. This mixture may also be administered through a nasogastric tube (CH8 or larger); it is important to flush the tube with water after administration. If switching from another antiplatelet agent to this medicine, start this medicine 24 hours after the last dose of the previous medicine. If a dose is missed, take only 1 tablet (the next scheduled dose) at the next scheduled dosing time. No dose adjustment is necessary in patients with renal impairment. No dose adjustment is necessary in patients with mild hepatic impairment. This medicine has not been studied in patients with severe hepatic impairment, and experience with its use in patients with moderate hepatic impairment is limited.

Child dose

Pediatric patients under 18 years of age: Safety and efficacy have not been established (see “Other” section).

This medication is an anticoagulant that prevents platelet aggregation in the blood to help reduce the risk of cardiovascular diseases like myocardial infarction or stroke. However, it may increase the risk of bleeding, and therefore should not be administered to patients with current bleeding or a history of intracranial hemorrhage. Patients scheduled for surgery should discontinue this medication at least 5 days prior to the procedure, as there may be an increased risk of bleeding during or after surgery. This drug should be used cautiously in patients with a high risk of bleeding, such as those who have recently had surgery or trauma or have a bleeding disorder. Furthermore, specific attention should be given when administering this medication to patients with certain liver diseases or those taking strong CYP3A4 inhibitors, as side effects may be aggravated. Patients taking such drugs should definitely inform their healthcare provider. During treatment, if symptoms such as sudden bleeding, easy bruising, shortness of breath, or dizziness occur, consultation with a doctor should be sought immediately. Particularly asthmatic patients or those with chronic obstructive pulmonary disease (COPD) may experience more frequent shortness of breath, necessitating caution. This drug has been reported to cause side effects such as arrhythmia and bradycardia; therefore, patients with heart disease or related symptoms should consult with their healthcare provider before use. Women who are pregnant or breastfeeding should consult with their healthcare provider before taking this medication, and women of childbearing age should take proper contraceptive measures to avoid pregnancy. Also, it is not recommended for children under 18 years of age as its safety and efficacy have not been established. Elderly patients or those with impaired kidney function should regularly undergo kidney function tests after taking this medication and report any side effects immediately. In the case of overdose, there is a significant increase in the risk of bleeding, and since there is currently no antidote for this drug, immediate medical attention is required. During treatment, interactions with other medications may occur, so it is essential to inform healthcare providers about all medications being taken and undergo periodic monitoring. Finally, this drug may cause symptoms such as dizziness or confusion, so caution is needed while driving or operating machinery.

Bleeding, intracranial hemorrhage, ocular hemorrhage, ear hemorrhage, hypotension, dyspnea, respiratory tract hemorrhage, gastrointestinal hemorrhage, diarrhea, nausea, dyspepsia, constipation, retroperitoneal hemorrhage, skin hemorrhage, rash, itching, muscle hemorrhage, urinary tract hemorrhage, reproductive tract hemorrhage, elevated blood creatinine, post-procedure bleeding, thrombotic thrombocytopenic purpura, bradyarrhythmia, atrioventricular block, angioedema, confusion, dizziness, syncope, headache, vertigo, ear hemorrhage, chest pain, pulmonary hemorrhage, cough, pneumonia, pulmonary edema, pharyngitis, upper respiratory infection, asthma, pleural effusion, bronchitis, pneumothorax, weakness, anaphylactic shock, epistaxis, hemoptysis, hematoma, cerebral hemorrhage, spinal canal stenosis, dementia, migraine, paralysis, gait abnormalities, rectal bleeding, anal bleeding, appendicitis, tendinopathy, bursitis, rhabdomyolysis, urinary tract infection, kidney stones, hepatitis, snoring, aneurysm, heart failure, palpitations, ventricular tachycardia, arrhythmia, ventricular fibrillation, cardiac arrest, ventricular fibrillation, urinary incontinence, kidney stones, nocturia, worsening of chronic kidney failure, cystitis, anemia, vestibular disorder, malignant neoplasm of male genital organs, chemical poisoning, post-procedure hematoma, laceration, road traffic accident, trauma, oral edema, flu-like symptoms, tuberculosis infection, hyperthermia, unspecified hernia, suffocation, generalized edema, thrombosis, deep vein thrombosis in legs, deep vein thrombosis, intracardiac thrombus, coagulopathy, thrombocytosis, speech disorder, cerebral hypoxia, scalp tenderness, peripheral neuropathy, neck stiffness, voice disorder, seizure, neuropathy, neuralgia, movement disorder, tremor, lower limb paralysis, coma, sensory loss, oral pain, gastritis, belching, irritable bowel syndrome, stomatitis, ulcerative stomatitis, benign gastrointestinal neoplasm, dental disease, tongue disease, tendinitis, arthritis, chondrocalcinosis, spondyloarthritis, arthritis, contact dermatitis, fungal dermatitis, skin diseases, erythematous rash, hyperkeratosis, acute urticaria, onychomycosis, hair loss, scleroderma, dermatofibroma, hyperhidrosis, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, lipodystrophy, dehydration, drowsiness, neurosis, depression, memory impairment, erectile dysfunction, restlessness, insomnia, anxiety, orthostatic hypotension, hypertension exacerbation, cyanosis, dyspnea, atrial arrhythmia, atrial fibrillation, conjunctival injection, eye pain, visual disturbances, arterial stenosis, angina, coronary thrombosis, cardiomyopathy, myocardial ischemia, cardiac compression syndrome, pericardial effusion, abscess, oral candidiasis, herpes zoster, bacterial infection, esophageal candidiasis, serum iron deficiency, lymphadenopathy, eosinophilia, leukocytosis, sexual dysfunction, benign prostatic hyperplasia, ovarian cyst, amenorrhea, vaginitis, loss of taste, abnormal sense of smell, elevated TSH, hypothyroidism, injection site reaction, injection site pain, tinnitus, ear pain, lymphadenopathy

This medication should be stored in a tightly sealed container to protect it from air or moisture exposure, and it is important to maintain a storage temperature between 1°C and 30°C. Storing it this way will help maintain the medication's efficacy and ensure safe use.

Appearance

Pink, biconvex, round film-coated tablet

Package unit

60 tablets (10 tablets/PTP*6)