Keometformin Tablets 15/850 mg

Adult dosage

The initial dose of this medication should be based on the patient's current treatment regimen. Start with one tablet per day, assessing the appropriateness of the treatment response, and gradually adjust the dosage. This medication should generally be divided and taken with meals to reduce gastrointestinal adverse reactions associated with metformin. Sufficient time is needed to assess the treatment response, and changes in HbA1C should be evaluated over a period of 8-12 weeks.

This medication helps control blood sugar levels. However, caution should be exercised for the rare side effect known as lactic acidosis while taking this medication. Lactic acidosis is a serious condition that occurs when there is an excessive accumulation of lactic acid in the body, and symptoms may include difficulty breathing, muscle pain, abdominal pain, and fatigue. If these symptoms occur, consult a physician immediately. Additionally, this medication should not be administered to patients with impaired kidney function or severe heart failure. Given that diminished kidney function can lead to drug accumulation in the body, this increases the risk of side effects. Regular kidney function testing is therefore essential. Patients with impaired liver function should also avoid using this medication, as compromised liver processing of drugs can aggravate side effects. Excessive alcohol intake may affect lactate metabolism when combined with this medication, making it risky; thus, avoidance of alcohol consumption is recommended. This medication may impose a burden on the heart, and patients with heart failure symptoms should be closely monitored. If symptoms of heart failure such as weight gain, swelling, or shortness of breath arise, medical personnel should be informed immediately. Patients with a history of bladder cancer or those with active bladder cancer should not use this medication and should report any new or worsening bladder-related symptoms to their doctor. Women who are pregnant, could become pregnant, or are breastfeeding should not take this medication. While using this medication, symptoms of hypoglycemia, in which blood sugar levels drop too low, may also occur, so caution is warranted when skipping meals or engaging in vigorous exercise. This is especially critical when taking other glucose-lowering agents concurrently. Elderly patients may be at risk for decreased kidney function, so careful dosage adjustments and regular monitoring of kidney function are advised during administration of this medication. If surgery or radiographic examinations using contrast agents are planned, the use of this medication should be temporarily halted, and it should only be resumed after confirming normal kidney function. While taking this medication, it is important to have regular blood sugar, hematological, and liver function tests to ensure there are no abnormalities.

Serious side effects

Severe lactic acidosis, severe hypoglycemia, severe allergic reactions, severe skin reactions, shortness of breath or difficulty breathing, asthma attacks, liver abnormalities (jaundice), severe neurological symptoms, severe edema, congestive heart failure, severe heart failure, cardiovascular collapse, acute myocardial infarction, sepsis, severe infections, bladder cancer, nitrogen blood uremia due to hypoxemia, fatal and non-fatal liver failure, severe rashes and blisters accompanied by fever

Mild side effects

• Upper respiratory tract infections
• diarrhea
• nausea
• headache
• urinary tract infections
• sinusitis
• dizziness
• lower limb edema
• weight gain
• muscle pain

This medication should be stored in a sealed container to protect it from air and moisture. The storage temperature should be maintained between 1 and 30 degrees Celsius, and it is advisable to avoid excessively hot or cold places.

Appearance

White to pale gray rectangular film-coated tablets

Package unit

30 tablets (10 tablets/PTP*3)