Piclo Tablet 250 mg (Clarithromycin)

Adult dosage

○ Adults: The usual dose is 250mg (potency) of clarithromycin twice daily. For severe infections, administer 500mg (potency) twice daily. The usual treatment duration is 7～14 days. In patients with renal failure whose creatinine clearance is 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer to these patients for more than 14 days. ○ Mycobacterial infections: Administer 500mg (potency) of this drug twice daily. In this case, it should be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, or rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this drug 3 times daily for 14 days in combination with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) 3 times daily for 14 days (days 1–14) and omeprazole 40mg once daily for 28 days (days 1–28).

Children's dosage

Children aged 12 years and older: Same as adults. Children under 12 years: Use clarithromycin dry syrup.

This medication should not be administered to certain patients. For example, those allergic to any of the ingredients contained in this medication or those who have had hypersensitivity to specific antibiotics should not use it. Additionally, patients with certain heart diseases, severe liver or kidney dysfunctions, and women who are pregnant or breastfeeding should refrain from taking this medication. Some medications may cause cardiac rhythm abnormalities or toxicity when taken together, so anyone who is taking drugs that interact with this medication should consult a physician. Caution should be exercised when using this medication in patients with impaired liver and kidney functions, those with heart diseases, and the elderly. Furthermore, taking this medication along with other antibiotics of a similar class can lead to the development of resistant bacteria, so caution is advised. Rarely, serious allergic reactions, skin rashes, liver dysfunction, kidney problems, gastrointestinal disorders, central nervous system symptoms, and other unusual symptoms may occur. If any such symptoms arise, discontinue use and inform a healthcare provider immediately. Long-term or high-dose use of this medication may lead to tinnitus or hearing loss, so consult a doctor if these symptoms occur. Gastrointestinal symptoms such as diarrhea or abdominal pain may occur during antibiotic use, which can be a sign of severe colitis. If symptoms persist, notify a healthcare provider immediately. This medication interacts with many other drugs; therefore, it is essential to inform healthcare providers of any medications currently being taken, especially when combined with heart-related medications, anticoagulants, hypoglycemic agents, and immunosuppressants. It is safer not to use this medication during pregnancy or breastfeeding, and if it must be used, consulting a physician is necessary. Children and the elderly may have different physiological functions, so careful monitoring is needed when using this medication for them. In the case of overdose, gastrointestinal disorders or neurological symptoms may occur, so the prescribed dosage must be adhered to. If an overdose is suspected, immediate medical attention is necessary. This medication should not be refrigerated during storage; it should be protected from direct sunlight and kept at room temperature.

Shock, anaphylactic symptoms, respiratory distress, convulsions, flushing, rash, itching, hives, skin redness, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, gas retention, diarrhea, oral mucosal erosion, epigastric pain, thirst, transient teeth discoloration, pancreatitis, increased amylase, dysgeusia, anorexia, constipation, discoloration of stools, membranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray findings, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute exacerbation of maxillary sinusitis, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucination, psychosis, depersonalization, tremors, numbness, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, elevated BUN, interstitial nephritis, kidney failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, dysgeusia, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, hearing impairment, hypoglycemia, tinnitus, hearing loss, purpuric rash, acute generalized eruption of pustules, soft tissue infection, candidiasis, gastroenteritis, infection, vaginitis, leukopenia, neutropenia, thrombocytosis, agranulocytosis, thrombocytopenia, anaphylactic-like reaction, angioedema, decreased appetite, insomnia, neuroexcitation, noise sensitivity, psychotic disorder, confused state, non-vertiginous dizziness, drowsiness, tremor, movement disorder, vestibular dizziness, cardiac arrest, atrial fibrillation, ectopic beats, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, distension, tongue discoloration, teeth discoloration, abnormal liver function tests, cholestasis, increased alanine aminotransferase, increased aspartate aminotransferase, elevated gamma-glutamyl transferase, hepatocellular jaundice, vesicular dermatitis, hyperhidrosis, papular rash, acne, Henoch-Schönlein purpura, muscle cramps, musculoskeletal stiffness, myopathy, elevated blood urea nitrogen, phlebitis at injection site, pain at injection site, inflammation at injection site, fever, asthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactic dehydrogenase, increased international normalized ratio, prolonged prothrombin time, urine discoloration, changes in mental administration, obsessive behavior, hypokalemia, hypoxemia

This medication may be sensitive to light, so it should be stored in a tightly closed container that blocks light. Additionally, it is important to maintain a normal temperature between 15 to 30 degrees Celsius when storing the medication, avoiding too high or too low temperatures.

Appearance

Oval film-coated tablet with a vanilla flavor and yellow color

Package unit

30 tablets/bottle, 100 tablets/bottle