Ceftriazole 2g (Ceftriaxone Sodium Hydrate)

Adult dosage

Adults and children over 12 years old should receive 1–2g (based on potency) of ceftriaxone by intravenous or intramuscular injection once a day. For infections caused by pathogens showing moderate susceptibility or severe disease, the dose may be increased to 4g (based on potency) once daily. For the treatment of gonorrhea, a single intramuscular injection of 250mg (based on potency) is recommended. To prevent infections before and after surgery, administer 1–2g (based on potency) once, 30-90 minutes prior to surgery.

Children's dosage

In neonates (within 14 days of birth), administer 20–50mg (based on potency) per kg of body weight once a day, not exceeding 50mg (based on potency). For infants and children (from 15 days to 12 years), 20–80mg (based on potency) per kg of body weight once a day.

This drug should not be mixed or administered simultaneously with solutions or drugs containing calcium. Particularly in neonates, it must not be used as it may form precipitates when combined with calcium. Patients with allergies to this drug or a history of hypersensitivity to cephalosporins or penicillins should not use it. Furthermore, it should not be administered to neonates with prematurity, jaundice, hypoalbuminemia, or acidosis. Care should be taken when administering this drug to patients with a history of drug allergies or those predisposed to allergic reactions such as asthma or rashes. Patients with severely impaired kidney function, elderly patients, or those in poor general health may require dose adjustment. The use of this drug can cause changes in blood cell counts, diarrhea, skin rashes, abnormal liver function, and various side effects, so any unusual symptoms should be reported to healthcare professionals immediately. In particular, if a severe allergic reaction or shock symptoms occur, administration should be stopped immediately and emergency treatment should be sought. This drug should only be used for the minimum duration necessary to prevent drug resistance, and regular monitoring of liver and kidney function tests is needed during administration. Additionally, caution is recommended when driving or operating machinery during treatment. When used in combination with other medications, it may affect kidney function, so follow the instructions of a professional for concurrent use. Pregnant or breastfeeding women should exercise caution when using this drug. Pediatric patients, especially neonates and premature infants, should avoid its use until safety has been established, and elderly patients may have a higher risk of side effects due to decreased body function. Finally, this drug should be used as soon as possible after preparation, and prepared solutions may lose effectiveness if not used within a certain time frame.

Serious side effects

Hives, severe swelling (edema), swelling, chest tightness, difficulty breathing, cold sweat, paleness, severe allergic reactions, high fever with severe rash, blisters, skin peeling, oral/eye mucosal pain, severe skin reactions, difficulty breathing or breathlessness, asthma attacks, respiratory problems associated with cough and fever, jaundice (yellowing of the skin or eyes), profound lethargy, liver abnormalities (jaundice), adrenal crisis

Mild side effects

• Eosinophilia
• leukopenia
• thrombocytopenia
• diarrhea
• rashes
• increased liver enzymes
• headaches
• dizziness
• bronchospasm
• loose stools

This drug should be stored in a sealed container to prevent exposure to air, preferably at room temperature between 1 to 30 degrees Celsius. This storage helps maintain the drug's effectiveness for a longer period.

Appearance

A colorless transparent vial containing white to pale yellow powder

Package unit

2g x 10 vials