Nicobai Tablet 1 mg (Varenicline Salicylate)

Adult dosage

After 1 week of dose titration, take 1 mg twice daily. Days 1–3: 0.5 mg once daily Days 4–7: 0.5 mg twice daily Day 8 until the end of treatment: 1 mg twice daily For patients who cannot tolerate adverse reactions to this medicine, the dose may be reduced temporarily or permanently. The treatment period is 12 weeks. For patients who successfully quit smoking with the first 12 weeks of treatment, an additional 12 weeks of this medicine is recommended to increase the likelihood of long-term abstinence. Take this medicine for an additional 12 weeks for a total treatment period of 24 weeks. No dose adjustment is necessary in patients with mild (estimated creatinine clearance > 50 mL/min and ≤ 80 mL/min) to moderate (estimated creatinine clearance ≥ 30 mL/min and ≤ 50 mL/min) renal impairment. In patients with severe renal impairment (estimated creatinine clearance < 30 mL/min), the recommended starting dose of varenicline is 0.5 mg once daily. If needed, the maximum dose is 0.5 mg twice daily. In patients with end-stage renal disease receiving hemodialysis, if well tolerated, a maximum dose of 0.5 mg once daily may be administered. No dose adjustment is necessary in patients with hepatic impairment.

Children's dosage

Under 18 years of age: Use is not recommended.

This drug is intended to aid smoking cessation; however, during use, psychiatric symptoms or suicidal tendencies may occur, requiring caution. If symptoms such as depression, anxiety, hallucinations, or aggressiveness manifest during treatment, the drug should be discontinued immediately and a doctor consulted. It should not be used in cases of hypersensitivity or known allergies to any of its components. Pregnant or breastfeeding women should use this medication cautiously and consult their doctor before use. Common gastrointestinal and psychiatric side effects may include nausea, headache, insomnia, and abnormal dreams. Nausea can be alleviated by adjusting the initial dosage; however, in severe cases, dosage reduction or discontinuation may be necessary. Caution should be exercised while performing hazardous activities such as driving or operating machinery, as symptoms like drowsiness or dizziness may occur. Although significant drug interactions with other medications have not been widely reported, it is advisable to avoid or minimize alcohol consumption. Elderly patients or patients with impaired renal function may require dosage adjustments, so follow a doctor's recommendations. In case of overdose, standard care should be taken; as there is no specific antidote, follow medical instructions accordingly. This medication should be stored out of reach of children and in its original container to maintain quality.

• Suicidal ideation
• suicidal behavior
• suicide
• changes in behavior or thoughts
• depression
• mania
• psychosis
• aggressive behavior
• hallucinations
• paranoia

This medication must be stored in a tightly sealed container to prevent the ingress of air or moisture. It is recommended to keep it at room temperature between 1 to 30 degrees Celsius.

Appearance

Light blue, double convex, oblong film-coated tablet

Package unit

28 tablets (14 tablets/PTP*2)