Clinfix Tablets 1 mg (Varenicline Salicylate)

Adult dosage

Patients should set a quit date and start taking this medicine 1 week before that date. Alternatively, they may begin quitting between day 8 and day 35 after starting this medicine. Take this medicine after meals with plenty of water. The recommended dosage is as follows: after dose titration over 1 week, administer 1 mg twice daily. Days 1 – 3: 0.5 mg once daily Days 4 – 7: 0.5 mg twice daily Day 8 – end of treatment: 1 mg twice daily For patients who cannot tolerate the adverse reactions of this medicine, the dose may be reduced temporarily or permanently. The treatment period is 12 weeks. For patients who successfully quit smoking after the first 12 weeks of treatment, an additional 12 weeks of treatment with this medicine is recommended to increase the likelihood of long-term abstinence. For patients who cannot or do not wish to stop smoking abruptly, consider gradually stopping smoking while taking this medicine. Reduce smoking by 50% compared with baseline within the first 4 weeks after starting treatment, and by an additional 50% over the next 4 weeks. Continue to reduce smoking so that complete cessation is achieved by week 12. Continue this medicine for an additional 12 weeks for a total treatment period of 24 weeks. Encourage patients to stop smoking sooner if they feel ready. Patients who fail to quit after the first 12 weeks of treatment, or who resume smoking after treatment, should review the reasons for failure and try again. However, there are no data demonstrating efficacy for an additional 12 weeks of treatment in patients who fail to quit during the initial 12 weeks or resume smoking after treatment. No dose adjustment is required in patients with mild (estimated creatinine clearance > 50 ml/min and ≤ 80 ml/min) to moderate (estimated creatinine clearance ≥ 30 ml/min and ≤ 50 ml/min) renal impairment. In patients with severe renal impairment (estimated creatinine clearance < 30 ml/min), the recommended starting dose of varenicline is 0.5 mg once daily. If needed, the maximum dose is 0.5 mg twice daily. In patients with end-stage renal disease receiving hemodialysis, if well tolerated, a maximum dose of 0.5 mg once daily may be administered. No dose adjustment is required in patients with hepatic impairment. Because renal function is more likely to be reduced in older adults, use caution when selecting the dose; monitoring renal function may be useful.

Children's dosage

Patients under 18 years of age: Use is not recommended.

This medication is used to help quit smoking. During the course of treatment, neuropsychiatric symptoms such as depression, anxiety, hallucinations, and aggression may occur, so caution is necessary. If thoughts or behaviors of suicide occur, discontinue use immediately and consult a doctor. This medication should be closely monitored for neuropsychiatric symptoms in patients with a history of psychiatric disorders. For pregnant individuals, it is important to carefully consider the risks to the fetus and the benefits of this medication, and breastfeeding women should discuss with their doctor whether to discontinue breastfeeding. This medication is not recommended for children or individuals under 18 years old. Elderly patients may require dosage adjustments based on renal function, so care is needed. Common side effects during medication include nausea, headache, insomnia, and abnormal dreams, and in some patients, these symptoms may persist. Serious side effects such as angioedema, cardiovascular issues, or severe skin reactions have rarely been reported, so any abnormal symptoms should be immediately reported to healthcare professionals. Caution should be exercised when driving or operating machinery, as drowsiness or dizziness may occur. Alcohol consumption may increase the risk of side effects, so it should be avoided or minimized during treatment. The risk of drug interactions with this medication is low; however, if other medications are being taken, inform a physician or pharmacist. In cases of overdose, seek medical assistance immediately, and keep this medication out of the reach of children. Medicines should be stored in their original containers to maintain quality.

• Suicidal thoughts
• suicidal behavior
• suicide
• changes in behavior or thoughts
• depression
• mania
• mood changes
• psychosis
• aggressive behavior
• hallucinations

This medication should be stored in a tightly sealed container to protect it from exposure to air and moisture. It is best kept at room temperature, specifically between 1 degree and 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness.

Appearance

Light blue, double-sided convex, rectangular film-coated tablets

Package unit

28 tablets (14 tablets/Blister × 2)