Neurodone Tablets 5 mg (Donepezil Hydrochloride Hydrate)

Adult dose

○ Adults: Administer donepezil hydrochloride 5 mg once daily at bedtime. If sleep disturbances such as abnormal dreams, nightmares, or insomnia occur, morning administration of this medicine may be considered. Since donepezil concentrations reach steady state 15 days after administration and the frequency of adverse reactions may be affected by the rate of dose escalation, administer the 5 mg dose for 4~6 weeks. After evaluating the clinical response during this period, the dose may be increased to 10 mg. When increasing the dose to 10 mg daily, monitor for gastrointestinal adverse reactions. If treatment with this medicine is stopped, its effects gradually decrease; no rebound effect occurs with abrupt discontinuation. ○ Female patients aged 85 years or older with low body weight: Adverse reactions occur frequently, so careful monitoring is required. Elderly women with low body weight should not exceed 5 mg daily.

Child dose

○ Children: There is no experience with use in children.

This medication contains the ingredient donepezil hydrochloride and is used for the treatment of symptoms of Alzheimer's-type dementia. This medication should not be administered to certain patients. For example, individuals allergic to this medication or its ingredients, pregnant women, or women who may become pregnant, and those with hereditary issues such as lactose intolerance should not use it. Patients with heart disease or heart rhythm issues should use this medication cautiously, as it may slow heart rate or cause arrhythmia. Additionally, those with a history of peptic ulcers or who are taking non-steroidal anti-inflammatory drugs should be cautious as it may affect gastrointestinal health. Patients with asthma or chronic obstructive pulmonary disease need to be careful as this medication can affect the bronchi and may worsen symptoms. Patients with extrapyramidal disorders, such as Parkinson's disease, should consult a physician before taking this medication. This medication can cause various adverse reactions, which in severe cases may include fainting, heart problems, gastrointestinal bleeding, liver function abnormalities, seizures, muscle problems, and more. If symptoms occur, immediate consultation with a physician is necessary. This medication can affect the heart and gastrointestinal tract, requiring regular health check-ups and symptom monitoring. Care should be taken when driving or operating machinery while taking this medication, as dizziness or drowsiness may occur. Be cautious of possible interactions with other medications. Particularly, when taken with medications that interfere with the metabolism of this medication in the liver, it may change the effectiveness, so all medications being taken should be disclosed to the physician. Pregnant or breastfeeding women are advised to avoid this medication, and if it must be taken, thorough consultation with a professional is necessary. Safety in children has not been established, so it is generally advised not to use it in children. In case of overdose, symptoms may include nausea, vomiting, severe muscle weakness, and difficulty breathing, requiring immediate emergency treatment. In cases of overdose, an antidote such as atropine may be used. This medication must be stored out of reach of children, and transferring it to another container should be avoided as it may lower the quality or pose a risk of accidents.

Syncope, bradycardia, heart block, QT interval prolongation, myocardial infarction, heart failure, peptic ulcer, perforated duodenal ulcer, gastrointestinal bleeding, hepatitis, liver dysfunction, jaundice, cerebral seizure, cerebral hemorrhage, cerebrovascular disorder, motor function disorder, ataxia, movement disorder, muscle tone abnormalities, tremors, involuntary movements, gait disturbances, abnormal posture, speech disorders, akinetic mute state, extreme muscle rigidity, dysphagia, tachycardia, blood pressure fluctuations, sweating, rhabdomyolysis, myalgia, weakness, dyspnea, acute pancreatitis, acute kidney failure, unexplained sudden death, cold, loss of appetite, hallucinations, agitation, aggressive behavior, anxiety disorder, insomnia, drowsiness, increased libido, talkativeness, mania, nightmares, nervousness, gibberish, delusions, depression, confusion, apathy, hyperactivity, increased libido, hypersexuality, dizziness, tremors, seizures, stupor, thoracic rigidity, bradycardia, palpitations, sinoatrial block, atrioventricular block, hypertension, hypotension, atrial fibrillation, torsades de pointes ventricular tachycardia, prolonged QT interval on electrocardiogram, diarrhea, nausea, vomiting, abdominal disorders, gastrointestinal bleeding, gastric and duodenal ulcers, constipation, saliva secretion, dysphagia, fecal incontinence, rash, itching, muscle cramps, myalgia, urinary incontinence, polyuria, urinary retention, headache, fatigue, pain, toothache, facial flushing, lethargy, asthenia, edema, fever, decreased body temperature, decreased hematocrit, leukopenia, anemia, thrombocytopenia, accidents, decreased appetite, urinary tract infection, petechiae, increased CPK, dehydration, hyperlipidemia, insomnia, hostility, irritability, drowsiness, depression, confusion, emotional instability, personality disorders, eczema, urinary incontinence, abdominal pain, weakness, fungal infection, influenza-like syndrome, allergies, soft tissue infection, fatigue, sepsis, facial edema, hernia, hypotension, ECG abnormalities, heart failure, constipation, gastroenteritis, fecal incontinence, dyspepsia, increased γ-GT, gastritis, periodontitis, gastric ulcer, periodontal abscess, abdominal distension, liver function abnormalities, belching, esophagitis, anal bleeding, diabetes, anemia, leukocytosis, weight loss, peripheral edema, edema, increased LDH, increased alkaline phosphatase, hypercholesterolemia, hypokalemia, hypoglycemia, weight gain, hyperbilirubinemia, increased BUN, B12 deficiency anemia, cachexia, increased creatinine, gout, hyponatremia, hypoalbuminemia, iron deficiency anemia, increased AST, increased ALT, arthritis, arthrosis, bone fracture, arthralgia, leg cramps, osteoporosis, anxiety, agitation, convulsions, transient mental disorders, gait disturbances, flat affect, delusions, dream abnormalities, cerebrovascular abnormalities, increased saliva secretion, ataxia, ecstasy-like state, vasodilation, cerebral hemorrhage, cerebral infarction, cerebral ischemia, dementia, extrapyramidal symptoms, generalized tonic-clonic seizures, hemiplegia, hypertonia, hypokinesia, pharyngitis, pneumonia, increased cough, bronchitis, rhinitis, asthma, skin ulcer, psoriasis, skin discoloration, herpes zoster, dry skin, hives, vesicular rash, conjunctivitis, glaucoma, visual disturbances, ear pain, tear abnormalities, urinary tract infection, cystitis, hematuria, vaginitis, dysuria, polyuria, proteinuria, abdominal pain, agitation, cholecystitis, confusion, convulsions, heart block, hemolytic anemia, hyponatremia, neuroleptic malignant syndrome, pancreatitis, rash, nausea, vomiting, excessive saliva secretion, sweating, hypotension, respiratory depression, weakness, convulsions, muscle weakness.

This medication should be stored in a tightly sealed container to prevent air exposure and is best kept at a temperature between 1 and 30 degrees Celsius. Proper storage can maintain the medication's effectiveness for a long time.

Appearance

White round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle