Citiril Tablet (Glimepiride)

Adult dose

Individual adjustments are made for each patient. Take with more than 1/2 cup of water without chewing. This medication is administered orally once daily. It should be taken before breakfast or immediately before the first meal. It is very important not to skip meals after taking the medication. For monotherapy, the initial dose is started at 1 mg of glimepiride once daily, and it is increased by 1 mg at intervals of 1 to 2 weeks. Generally, when doses of 4 mg or more are administered, additional effects are minimal; however, some patients may benefit from increasing to 6 mg (or 8 mg) for better metabolic control. If a dose of 4 mg daily fails, consider switching to insulin therapy first, and if not, consider combining with insulin or other oral antidiabetic drugs.

This medication should not be used in patients with insulin-dependent diabetes or in patients with diabetic ketoacidosis or in a comatose state. Moreover, patients who have had hypersensitivity reactions to this medication or to sulfonylureas or sulfonamide drugs should not be administered this medication. For patients with severe liver or kidney dysfunction, transitioning to insulin therapy is recommended instead of using this medication. Women who are pregnant or may become pregnant, and those who are breastfeeding should also avoid using this medication. In cases of severe infections, pre- and post-surgical conditions, or in patients with severe trauma, insulin therapy is recommended. Patients with gastrointestinal disorders may have impaired food absorption, leading to a risk of hypoglycemia, and should exercise caution. This medication contains lactose, so patients with lactose intolerance or certain genetic metabolic disorders should not take it. During the initial phase of treatment, there is a high risk of hypoglycemia, so careful monitoring of blood sugar is necessary, especially for patients with poor nutritional status, irregular eating habits, the elderly, and those with impaired kidney or liver function. Patients who consume alcohol or have other endocrine disorders may also be at increased risk of hypoglycemia. Furthermore, this medication contains Yellow No. 4 dye, so caution should be exercised by patients allergic to this component. This medication may cause hypoglycemia, which can manifest as symptoms such as headache, severe hunger, nausea, fatigue, confusion, drowsiness, and in severe cases, loss of consciousness. Visual disturbances, gastrointestinal symptoms, liver dysfunction, blood abnormalities, and allergic reactions have also been reported, so if any abnormal symptoms arise, immediate consultation with a physician is required. When taking this medication, dietary and exercise regimens should be followed, and it is crucial to take it regularly. If hypoglycemia occurs, consuming foods containing sugar immediately can alleviate symptoms, and it is advisable to always carry sugar. When taken with other medications, interactions may occur, so all medications being taken should be reported to the healthcare provider. In particular, some antibiotics, antifungals, beta-blockers, and steroids may alter the effectiveness of this medication. Pregnant or breastfeeding women are encouraged to consider insulin therapy instead of this medication due to potential effects on the fetus or newborn. The safety and efficacy of this medication in children under 18 years have not been established, and in the elderly, dosage adjustments may be necessary due to declining kidney function. In the case of overdose, severe hypoglycemia may occur, necessitating immediate hospital treatment, and if symptoms of hypoglycemia are severe, a glucose injection may be required. This medication should be stored out of reach of children and kept securely in its original container.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, severe rash with fever, blisters, skin peeling, pain in oral/eye mucosa, severe skin adverse reactions, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities accompanied by coughing and fever, yellowing of the skin or eyes (jaundice), profound lethargy, liver dysfunction (jaundice), sudden and severe

Mild side effects

• Headache
• severe hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• anxiety
• aggression
• decreased concentration
• reduced motivation

This medication should be stored in a tightly closed container to protect it from air and moisture. The recommended storage temperature is room temperature between 1 to 30 degrees Celsius.

Appearance

Green oval-shaped tablet

Package unit

30 tablets/bottle, 300 tablets/bottle