Telogrel Tablets (Clopidogrel Hydrogen Sulfate)

Adult dose

○ Adults 1. For patients with ischemic stroke, myocardial infarction, or peripheral arterial disease, administer clopidogrel 75 mg orally once daily. 2. For patients with acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction), begin treatment on the first day with a loading dose of 300 mg of this medicine once daily, followed by a maintenance dose of 75 mg once daily orally. In this case, aspirin 75 ～ 325 mg should be administered concomitantly with this medicine once daily. 3. For patients with atrial fibrillation, administer 75 mg of this medicine orally once daily. In this case, aspirin 75 ～ 100 mg should be administered concomitantly with this medicine once daily. ○ Patients with renal impairment: Treatment experience in patients with renal impairment is limited. ○ Patients with hepatic impairment: Treatment experience in patients with moderate hepatic disease with a bleeding diathesis is limited. This medicine may be administered without regard to food.

This medication helps to prevent platelets from aggregating, promoting normal blood flow. Before taking this medication, patients with reduced function of a specific enzyme, CYP2C19, due to genetic factors should consult with their doctor as it may reduce the drug's effectiveness. Additionally, combining this medication with other drugs that activate CYP2C19 may increase the risk of bleeding, so it is advisable not to take them together. Patients allergic to this drug or its components, those with bleeding disorders, severely impaired liver function, breastfeeding mothers, and individuals with certain genetic disorders such as lactose intolerance should not take this medication. Patients at high risk of bleeding or with bleeding disorders should be administered this drug with caution, and bleeding should be monitored frequently through blood tests. If surgery is planned, discontinue this drug 5-7 days before the procedure and resume it after hemostasis is achieved. The risk of bleeding may increase when this drug is combined with other medications that have bleeding risks, so caution is required. There may be prolonged bleeding time during treatment; thus, if there is a bleeding site or if the bleeding persists, inform your physician immediately. Rarely, severe blood disorders may occur, characterized by a sudden drop in platelet count, so seek immediate medical attention if abnormal symptoms arise. Taking this medication may result in side effects such as gastrointestinal disturbances, diarrhea, headache, dizziness, rash, and in rare cases, serious bleeding or allergic reactions. During pregnancy, it should be taken only when necessary, considering the potential effects on the fetus, and during breastfeeding, one must carefully decide regarding breastfeeding as the drug can be excreted in breast milk. Safety and efficacy in children have not yet been established, so it is advisable not to use it in this population. Elderly patients have a heightened risk of bleeding and other side effects due to decreased bodily function, and therefore require dosage adjustment and monitoring. Patients with impaired renal function should also be administered this drug with caution, although specific dosage adjustment is not necessary. In case of overdose, the risk of bleeding may increase, and currently, there is no antidote for this drug, but platelet transfusion may be used to control bleeding if necessary. This medication should be kept out of reach of children and should not be transferred to other containers. During the course of treatment, it is essential to inform your physician or dentist of this medication before starting any new medications or surgical procedures.

Hemorrhage, gastrointestinal bleeding, hospitalization-required bleeding, purpura, contusion, hematoma, epistaxis, hematoma, hematuria, intraocular hemorrhage, intracranial hemorrhage, significant bleeding, minor bleeding, severe hemorrhage, fatal bleeding, hemorrhagic stroke, thrombocytopenia, neutropenia, aplastic anemia, abdominal pain, dyspepsia, diarrhea, rash, pruritus, headache, dizziness, chest pain, accidental injury, influenza-like illness, pain, fatigue, edema, hypertension, depression, upper respiratory tract infection, dyspnea, rhinitis, bronchitis, cough, urinary tract infection, syncope, palpitations, asthenia, fever, hernia, heart failure, atrial fibrillation, leg cramps, sensory deficit, neuralgia, paresthesia, dizziness, constipation, nausea, elevated liver enzymes, gout, hyperuricemia, arthralgia, low back pain, anxiety, insomnia, anemia, pneumonia, sinusitis, eczema, skin ulcer, cystitis, cataract, conjunctivitis, decreased motor function, tremor, voice disturbance, abnormal gait, hyperkinesia, ataxia, perceptual anomalies, insomnia, depression, forgetfulness, hypomania, abnormal thoughts, abnormal behavior, arthritis, gynecomastia, weight loss, weight gain, facial flushing, rigidity, facial edema, hematochezia, thrombocytopenia, cerebral hemorrhage, gingival bleeding, cough, visual disturbances, visual field defects, dry eye syndrome, temporary blindness, congestion, tinnitus, urinary dysfunction, polyuria, non-protein nitrogen increase, uremia, elevated blood urea nitrogen, hypoglycemia, ALT elevation, leg edema, arrhythmia, bradycardia, contact dermatitis, elevated prostate-specific antigen, cholecystitis, hematemesis, spinal hematoma, thrombocytopenia, thrombocytopenic purpura, vasculitis, hypotension, bronchospasm, interstitial pneumonia, eosinophilic pneumonia, colitis, pancreatitis, gastritis, stomatitis, hepatitis, acute liver failure, hemorrhagic gastroenteritis, duodenal ulcer, gastric ulcer, perforated gastric ulcer, upper gastrointestinal ulcer bleeding, distension, hyperbilirubinemia, infectious hepatitis, fatty liver, hemorrhagic arthropathy, hematuria, hemoptysis, retroperitoneal hemorrhage, surgical site bleeding, pulmonary hemorrhage, anaphylactoid reaction, serum sickness, confusion, hallucination, taste alteration, loss of taste, angioedema, vesicular dermatitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, drug-induced hypersensitivity syndrome, eosinophilia, drug rash, lichen planus, glomerulonephritis, gynecomastia, fever, abnormal liver function tests, elevated blood creatinine

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. It is best kept at room temperature between 1 to 30 degrees Celsius, away from extreme heat or cold.

Appearance

Pink, round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle, 300 tablets/bottle