Richmentin Tablet 375 mg (Amoxicillin-Potassium Clavulanate)

Adult dose

In adults and children aged 12 years or older or weighing 40 kg or more, administer 250 mg/125 mg of amoxicillin/clavulanate potassium orally three times a day every 8 hours. In cases of severe or respiratory infections, the dosage may be increased to 500 mg/125 mg at a time. For patients with renal impairment, adjust the dosage according to creatinine clearance. - For creatinine clearance of 10 to 30 mL/min: administer 250 mg/125 mg every 12 hours.

Child dose

Administer the same as for adults and children aged 12 years or older or weighing 40 kg or more, adjusting the dosage according to creatinine clearance in cases of renal impairment.

This drug is a beta-lactam antibiotic and should not be administered to patients with hypersensitivity to penicillins or cephalosporins. Special caution is needed for patients with infectious mononucleosis or lymphocytic leukemia due to a higher risk of rashes. Patients with a history of liver dysfunction or jaundice should also be cautiously considered before use. Patients with impaired liver function or moderate to severe renal impairment may have increased drug concentration, necessitating careful dosage adjustments and administration intervals. Patients with allergic tendencies, elderly patients, or those in poor general condition should also be closely monitored for adverse reactions. Severe vomiting or diarrhea may impair proper absorption of the drug. This medication may cause gastrointestinal side effects such as diarrhea, vomiting, and abdominal pain, and in rare cases, serious issues like pseudomembranous colitis or acute pancreatitis may occur. If any adverse symptoms manifest, its use should be immediately discontinued and a physician consulted. Symptoms of liver dysfunction have also been reported; thus, continuous liver function testing during treatment or after discontinuation is vital, especially in the elderly or males. Allergic reactions can cause skin rashes, urticaria, and, rarely, serious skin diseases or anaphylactic shock, necessitating immediate discontinuation of the drug if symptoms appear. Hematological side effects such as leukopenia and thrombocytopenia have been rarely reported, which may lead to bleeding tendencies. Central nervous system symptoms such as drowsiness, anxiety, and seizures may occur rarely, and renal dysfunction has also been reported, thus regular monitoring is required. This drug can alter the intestinal flora, affecting the efficacy of other medications; therefore, it should be taken as directed by a physician, especially when used in conjunction with oral contraceptives or anticoagulants. It is advisable to avoid use during pregnancy, particularly in the first trimester, and caution is needed during breastfeeding as adverse effects may occur in infants. It is not recommended for children, especially those under 12 years of age or weighing less than 40 kg. In the elderly, there is a higher risk of side effects due to reduced body function, and caution is necessary due to bleeding risks secondary to vitamin K deficiency. Overdosing of this medication may result in gastrointestinal symptoms, renal failure, neural abnormalities, and in suspicion of overdose, treatment should be halted immediately and appropriate medical care obtained. Store in a dry place at or below 25 degrees Celsius in a tightly closed container. Before use, confirm if there has been any hypersensitivity to beta-lactam antibiotics.

Serious side effects

Urticaria, severe swelling (edema), tightness in the chest, difficulty breathing, cold sweat, pallor, anaphylaxis, Stevens-Johnson syndrome, shock, severe rash accompanied by high fever, blisters, skin peeling, mucosal pain in the mouth/eyes, shortness of breath or difficulty breathing, asthma attacks, respiratory distress accompanied by cough and fever, jaundice (yellowing of skin or eyes), extreme drowsiness, sudden and severe headache, lightning headache, seizures

Mild side effects

Diarrhea, indigestion, stomatitis, gastritis, glossitis, nausea, vomiting, loss of appetite, abdominal pain, bloating, constipation, colonic pain, acid reflux, loose stools, dry mouth, acute pancreatitis, candidiasis, antibiotic-associated colitis, colitis with blood in stools, itching, polymorphic erythema, dermatitis, toxic epidermal necrolysis, vesicular exanthema, acute generalized exanthematous pustulosis, thrombocytopenia, anemia, thrombocytopenic purpura, eosinophilia, leukopenia

This medication should be kept in a tightly sealed container to prevent moisture and stored in a dry place below 25 degrees Celsius. Proper storage ensures the medication maintains its efficacy and prevents degradation.

Appearance

This medication is an oval film-coated tablet, white or almost white in color.

Package unit

100 tablets (10 tablets/PTP X 10), 80 tablets (8 tablets/PTP X 10)