Clarithromycin 250 mg Tablets

Adult dosage

○ Adults : The usual dose of clarithromycin is 250 mg (potency) twice daily. For severe infections, administer 500 mg (potency) twice daily. The usual duration of treatment is 7～14 days. In patients with renal impairment and a creatinine clearance of 30mL/min or less, the dose should be reduced by half. That is, administer 250 mg (potency) once daily, or, for severe infections, 250 mg (potency) twice daily. Do not administer for more than 14 days to these patients. ○ Mycobacterial infections : Administer 500 mg (potency) of this product twice daily. In this case, it must be administered concomitantly with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers : Administer 500 mg (potency) of this product three times daily for 14 days concomitantly with omeprazole 40 mg once daily, followed by omeprazole 40 mg once daily for 14 consecutive days. That is, administer clarithromycin 500 mg (potency) three times daily for 14 days (days 1～14) and omeprazole 40 mg once daily for 28 days (days 1～28).

Children's dosage

Children 12 years of age and older: Same as adults. For children under 12 years of age, use clarithromycin dry syrup.

This medication should not be used in patients allergic to specific ingredients. Patients who have had allergies to antibiotics in the same class should also avoid using this medication. Additionally, patients currently taking certain heart-related medications should take caution as there is a risk of heart rhythm abnormalities when using this medication. Patients with severely reduced liver or kidney function should consult with a healthcare professional before using this medication. It is safest for pregnant or breastfeeding women to avoid this medication. This medication can rarely cause serious allergic reactions or skin disorders, so if any unusual symptoms appear, use should be stopped immediately and a healthcare professional should be informed. While taking this medication, gastrointestinal disturbances, liver function abnormalities, and kidney function deterioration may occur, so regular monitoring may be necessary. Due to the potential for many drug interactions, if other medications are being taken, it is essential to inform the healthcare provider and exercise caution. Special care is needed when used in patients with certain heart diseases, liver diseases, kidney diseases, or hypokalemia. Elderly patients may experience a higher risk of side effects due to reduced body functions, so careful dosing is required. Long-term or excessive use of this medication may lead to hearing damage or other side effects, so prescribed dosages and regimens must be strictly followed. Caution is advised as dizziness or confusion may occur when driving or operating machinery. If persistent diarrhea or abdominal pain occurs while taking this medication, it is important to consult with a healthcare professional immediately. In cases of overdose, proper treatment such as gastric lavage is required, and care should be taken as it is not removed by hemodialysis. This medication contains lactose, so patients with lactose intolerance should discuss with their healthcare provider before taking it.

Shock, anaphylactic symptoms, dyspnea, seizures, flushing, rash, pruritus, urticaria, skin flushing, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, transient teeth discoloration, pancreatitis, increased amylase, dysgeusia, anorexia, constipation, discoloration of stool, pseudomembranous colitis, hemorrhagic colitis, fever, cough, eosinophilia, eosinophilic lung infiltrates, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, seizures, tremors, paresthesia, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash with eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, increased γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, anorexia, dark urine, pruritus, abdominal tenderness, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, myalgia, weakness, elevated CPK, increased serum myoglobin, increased urinary myoglobin, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, ageusia, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, tinnitus, auditory impairment, hypoglycemia, tinnitus, hearing loss, vomiting, purpuric rash, acute generalized pustular rashes, leukopenia, neutropenia, thrombocytosis, agranulocytosis, thrombocytopenia, anaphylactic reaction, angioedema, decreased appetite, insomnia, nervousness, noise intolerance, psychotic disorder, confused state, abnormal dreams, muscle cramps, musculoskeletal rigidity, myopathy, elevated blood urea, intravenous site phlebitis, injection site pain, injection site inflammation, fever, asthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated alkaline phosphatase in blood, increased lactate dehydrogenase, increased INR, prolonged prothrombin time, urine discoloration, vasodilation, cardiac arrest, atrial fibrillation, ectopic beats, palpitations, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, hyperhidrosis, papular rash, acne, Henoch-Schönlein purpura

This medication should be stored in a tightly sealed container to protect it from exposure to air or moisture. The storage temperature should be kept between 1 to 30 degrees Celsius.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle