Ceclarithin 250 mg (Clarithromycin)

Adult dosage

○ Adults: The usual dose of clarithromycin is 250mg (potency) per dose twice daily; for severe infections, administer 500mg (potency) per dose twice daily. The usual treatment duration is 7～14 days. In patients with renal impairment and creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) per dose twice daily. Do not administer to these patients for more than 14 days. ○ Mycobacterial infections: Administer 500mg (potency) of this medicine per dose twice daily. In this case, it should be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine 3 times daily for 14 days in combination with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

○ For children aged 12 years or older, use the same dosage as for adults; for children under 12 years of age, use clarithromycin dry syrup.

This medication should not be used in patients with allergies to certain ingredients. Patients who have had hypersensitivity reactions to clarithromycin or similar antibiotics should not take this drug. Additionally, it is unsafe for patients with severe liver impairment, severely poor kidney function, and those taking certain heart-related medications. Pregnant or nursing women should not take this medication, nor should it be administered to patients with central nervous system infections. This drug can affect liver and kidney function, so caution is necessary for patients with liver or kidney disease. Care should also be taken in the elderly or those with heart disease. While taking this medication, symptoms such as allergic reactions, gastrointestinal disturbances, skin rashes, liver function abnormalities, kidney function abnormalities, or central nervous system symptoms may occur, and if any unusual symptoms appear, one should consult a doctor immediately. This medication may interact with other drugs, so it’s important to inform healthcare personnel of any other medications being taken, particularly heart-related medications, blood coagulation drugs, certain antibiotics, antifungals, antivirals, and hypoglycemics. Overdose may cause gastrointestinal disturbances or central nervous system symptoms, so prescribed doses should be followed. Care should be taken while driving or operating machinery, as dizziness or confusion may occur. Prolonged or repeated use may lead to resistant bacteria, so it should only be used for the appropriate duration as directed by a physician. This medication contains lactose, so patients with lactose intolerance should not take it. Store in a closed container, away from direct sunlight, at room temperature, and do not refrigerate.

Shock, anaphylactic symptoms, dyspnea, convulsions, flushing, rash, itching, hives, skin flushing, angioedema, arthralgia, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, discomfort, gas retention, diarrhea, oral mucosal erosion, upper abdominal pain, cramp-like upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, dysgeusia, anorexia, constipation, stool discoloration, pseudomembranous colitis, hemorrhagic colitis, bloody stools, fever, cough, dyspnea, chest X-ray abnormalities, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, ageusia, anosmia, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash associated with eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, increased γ-GTP, elevated LDH, increased ALP, elevated total bilirubin, increased serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, taste disturbance, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, tinnitus, hearing impairment, hypoglycemia, tinnitus, hearing loss, vomiting, nausea, abdominal pain, purpuric rash, acute pancreatitis, increased amylase, leukopenia, neutropenia, thrombocytosis, agranulocytosis, thrombocytopenia, anaphylactic reactions, vascular edema, anorexia, decreased appetite, hypoglycemia, insomnia, anxiety, irritability, noise sensitivity, psychotic disorder, confusional state, depersonalization, depression, disorientation, hallucinations, abnormal dreams, mania, dysgeusia, headache, loss of consciousness, movement disorders, non-vertiginous dizziness, drowsiness, tremors, convulsions, ageusia, abnormal olfaction, anosmia, vestibular dizziness, hearing impairment, hearing loss, cardiac arrest, atrial fibrillation, ECG QT prolongation, ectopic beats, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, abnormal liver function tests, cholestasis, hepatitis, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated gamma-glutamyl transferase, liver failure, hepatocellular jaundice, rash, hyperhidrosis, vesicular dermatitis, papular rash, acne, Henoch-Schonlein purpura, acute generalized pustular dermatosis, muscle cramps, musculoskeletal rigidity, myalgia, rhabdomyolysis, myopathy, elevated serum creatinine, elevated serum urea, renal failure, nephritis, injection site phlebitis, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color, changes in mental administration, obsessive behavior, hypokalemia, hypoxemia

This medication may be sensitive to air or moisture, so it should be stored in a sealed container. Additionally, it is best to keep it at room temperature between 1 to 30 degrees Celsius, not in excessively hot or cold places.

Appearance

Yellow oval film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle