Medication info
Florine 250 mg (Ciprofloxacin Hydrochloride Hydrate)

Florine 250 mg (Ciprofloxacin Hydrochloride Hydrate)

Prescription medicationTablet경구
Ingredient · strength
Ciprofloxacin Hydrochloride Hydrate›291mg / 1 tablet
Manufacturer / importer
(주)한국피엠지제약
Appearance
White round film-coated tablets
Packaging
30 tablets/bottle, 300 tablets/bottle
Approval status
Active

MFDS item code 201800924 · Approved 2018.02.26

Summary

Main use
Treatment effect for respiratory infections and urinary tract infections
Who takes it
Adults
Adult dose
250 to 500 mg orally twice a day between meals. In cases of severe complicated infections, the dose may be increased to 750 mg twice a day. For acute infections, treatment is usually for 5 to 10 days, and even after symptoms resolve, the medication should be administered for at least 3 additional days. Patients with renal impairment should adjust the dosage according to creatinine clearance, and patients undergoing hemodialysis or peritoneal dialysis should take 250 to 500 mg after each dialysis session.

Ingredients

Manufacturer
(주)한국피엠지제약

Efficacy & effects

Treatment effect for respiratory infections and urinary tract infections

  • Acute bronchitis
  • respiratory infections
  • community-acquired pneumonia
  • pharyngitis
  • tonsillitis
  • laryngitis
  • otitis externa
  • chronic cholesteatomatous otitis media
  • chronic otitis media
  • bacterial prostatitis
  • acute simple cystitis
  • acute pyelonephritis
View approved original text

This medication is used to treat infections caused by various bacteria. It is particularly effective against several harmful bacteria including Escherichia coli, Shigella, and Salmonella. It is suitable for the treatment of respiratory infections excluding acute bronchitis and community-acquired pneumonia, and it is also used for infections of the ear, nose, and throat. Furthermore, it helps with bacterial prostatitis, acute urinary tract infections, gonococcal cervicitis and urethritis, gastrointestinal infections, and infections of bile ducts. It is used to treat bacterial infections in various sites including skin and soft tissue infections, bone and joint infections, gynecological infections, and peritonitis; however, its use prior to surgery is restricted. As a fluoroquinolone, there is a possibility of serious adverse reactions in some cases, hence it is used only when there are no alternative treatments for certain infections. This medication is useful for effectively treating various bacterial infections.

How to take

Adult dose

250 to 500 mg orally twice a day between meals. In cases of severe complicated infections, the dose may be increased to 750 mg twice a day. For acute infections, treatment is usually for 5 to 10 days, and even after symptoms resolve, the medication should be administered for at least 3 additional days. Patients with renal impairment should adjust the dosage according to creatinine clearance, and patients undergoing hemodialysis or peritoneal dialysis should take 250 to 500 mg after each dialysis session.

Precautions

This medication may cause serious adverse effects such as tendinitis or tendon rupture, peripheral neuropathy, and central nervous system problems, so caution is advised. In particular, patients with severe myasthenia gravis may experience worsening symptoms with this medication and should not use it. If serious adverse effects occur, discontinue the medication immediately and consult a doctor. This medication should be used restrictively for certain infections and is safe only when there are no alternative treatments available. Elderly patients, those with reduced kidney function, and patients with a history of seizures should use this medication cautiously as they are at higher risk of side effects. It is safe to avoid this medication if pregnant or breastfeeding, as well as in growing children under 18 years of age and patients with epilepsy. This medication can interact with other drugs, so it is essential to inform your doctor or pharmacist if you are taking other medications. If symptoms such as muscle pain, tendon pain, visual disturbances, mental changes, or severe diarrhea occur during treatment, consult medical personnel immediately. Photosensitivity reactions may occur, so avoid strong sunlight or UV exposure, and discontinue the medication if symptoms arise. Patients with diabetes who require blood sugar control should closely monitor blood sugar fluctuations, and seek immediate treatment if hypoglycemic symptoms appear. This medication requires caution during driving or operating machinery, and symptoms may worsen if taken with alcohol. In cases of overdose, kidney function should be closely monitored, and appropriate emergency measures should be taken if necessary. This medication has not established safety in children and adolescents, so it is recommended not to use it. When storing, keep out of reach of children and avoid direct sunlight or UV exposure.

Side effects and when to seek care immediately

Serious side effects

Tendinitis, tendon rupture, peripheral neuropathy, central nervous system effects, exacerbation of severe myasthenia gravis, anaphylactic reactions, anaphylactoid reactions, shock, serum-sickness like reactions, seizures, delirium, convulsions, toxic psychosis, coma, altered consciousness, visual disturbances, paralysis, bone marrow suppression, abnormal liver function tests, jaundice, liver dysfunction, liver necrosis, systemic pustular rash, mucocutaneous syndrome (Stevens-Johnson syndrome), toxic epidermal necrolysis, acute.

Mild side effects

  • Headache
  • dizziness
  • sleep disorders
  • taste disorders
  • insomnia
  • sensory disturbances
  • tremors
  • drowsiness
  • migraines
  • coordination disorders
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  • visual disturbances
  • tinnitus
  • hearing loss
  • nausea
  • diarrhea
  • loss of appetite
  • gastric discomfort
  • vomiting
  • gastrointestinal and abdominal pain
  • abdominal distension
  • dyspepsia
  • rash
  • itching
  • hives
  • joint pain
  • musculoskeletal pain
  • myalgia
  • arthritis
  • increased muscle tension and cramps
  • muscle weakness
  • rash
  • itching
  • hives
  • swelling
  • sweating.

Not everyone experiences these, and they can vary from person to person.

Storage

This medication may be sensitive to air or moisture; therefore, it must be stored in a tightly sealed container. Additionally, to maintain the drug's effectiveness, it is essential to store it at room temperature between 1 degree and 30 degrees Celsius.

Appearance and packaging

Appearance

White round film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.