Adone Tablet 10 mg (Donepezil Hydrochloride Monohydrate)

Adult dose

○ Adults: Administer donepezil hydrochloride 5 mg once daily at bedtime. If sleep disturbances such as unusual dreams, nightmares, or insomnia occur, taking this medicine in the morning may be considered. Since donepezil concentrations reach steady state 15 days after administration and the incidence of adverse reactions may be affected by the rate of dose escalation, administer the 5 mg dose for 4~6 weeks. After assessing the clinical response during this period, the dose may be increased to 10 mg. When increasing the dose to 10 mg daily, use with caution regarding gastrointestinal adverse reactions. If this medicine is discontinued, its effects gradually diminish; no rebound effect occurs with abrupt discontinuation. ○ Women aged 85 years and older who are underweight: Careful monitoring is required because adverse reactions occur more frequently. Underweight elderly women should not exceed 5 mg per day.

Child dose

○ Children: There is no experience with use in children.

This medication contains Donepezil Hydrochloride and is used for the treatment of Alzheimer's type dementia. Firstly, this medication should not be used in patients with hypersensitivity to Donepezil Hydrochloride or any component of this medication, women who are pregnant or may become pregnant, and nursing mothers. Patients with heart disease, especially those with bradycardia or cardiac conduction disorders, should use this medication with caution as bradycardia or arrhythmia may occur. Patients on nonsteroidal anti-inflammatory drugs or with a history of peptic ulcers should be cautious, as increased gastric acid secretion and enhanced gastrointestinal motility may worsen symptoms. Patients with a history of asthma or obstructive pulmonary disease should be careful, as bronchoconstriction and increased mucus secretion may worsen symptoms. Patients with extrapyramidal disorders such as Parkinson's disease should be cautious with this medication, as cholinergic effects may exacerbate their symptoms. This medication contains Yellow No. 5 dye, so patients with allergies to this component should be careful. During treatment, severe side effects such as cardiac-related adverse reactions, gastrointestinal bleeding, liver function abnormalities, cerebrovascular accidents, extrapyramidal disorder symptoms, neuroleptic malignant syndrome, rhabdomyolysis, respiratory distress, acute pancreatitis, acute kidney failure, and sudden death may occur. If any unusual symptoms arise, immediately discontinue the medication and consult a healthcare professional. Common side effects may include nausea, vomiting, diarrhea, loss of appetite, dizziness, insomnia, headache, fatigue, and muscle pain, which are generally transient and mild. This medication is approved only for use in patients with Alzheimer's type dementia and should not be used for other forms of dementia or memory disorders. Treatment should be conducted under the diagnosis and supervision of an experienced physician, regularly assessing the effectiveness and considering discontinuation if necessary. Patients with heart conditions may experience bradycardia, heart block, QT interval prolongation, and may require an electrocardiogram. This medication may increase gastric acid secretion and enhance gastrointestinal motility, so patients with a history of gastric ulcers should be carefully monitored for worsening symptoms. Neuropsychiatric side effects may include hallucinations, agitation, aggressive behavior, anxiety, and depression, and adjustment of the dosage or cessation of treatment may be necessary if symptoms are severe. This medication may affect driving or operating machinery, so caution is advised at the beginning of treatment or when changing the dosage. It is advised that pregnant or nursing women do not use this medication, and if necessary, treatment should be conducted after consultation with a specialist. This medication may interact with various drugs, especially those that affect CYP3A4 or CYP2D6 enzymes, and caution is advised when used in combination with those medications. In cases of overdose, symptoms may include nausea, vomiting, bradycardia, hypotension, respiratory depression, and seizures, and treatment with an antidote such as atropine should be administered. This medication has not been established to be safe for children and should not be used; it should be stored out of reach of children.

• Syncope
• bradycardia
• heart block
• prolonged QT interval
• myocardial infarction
• heart failure
• peptic ulcer
• perforated duodenal ulcer
• gastrointestinal bleeding
• hepatitis

This medication should be stored in a tightly closed container to prevent air and moisture from entering, and it is best to keep it at room temperature between 1 and 30 degrees Celsius. This will help maintain the medication's effectiveness.

Appearance

Yellow round film-coated tablets

Package unit

30 tablets/bottle