Oavi Tablet 10 mg (Solifenacin Succinate)

Adult dosage

The usual recommended dose for adults (including elderly patients) is 5mg once daily. If necessary, the dose may be increased to a maximum of 10mg once daily. This medicine may be taken with or without food and should be swallowed whole with water. Dosage adjustment is required for the following patients. 1. Patients with renal impairment: No dosage adjustment is necessary in patients with mild or moderate renal impairment (creatinine clearance>30ml/min). Use with caution in patients with severe renal impairment (creatinine clearance≤30ml/min), and do not exceed 5mg once daily. 2. Patients with hepatic impairment: No dosage adjustment is necessary in patients with mild hepatic impairment. Use with caution in patients with moderate hepatic impairment (Child-Pugh Class B), and do not exceed 5mg once daily. 3. Patients receiving strong cytochrome P450 3A4 (CYP3A4) inhibitors: For patients receiving ketoconazole or another strong CYP3A4 inhibitor (e.g., ritonavir, nelfinavir, itraconazole), limit the maximum daily dose to 5mg.

This medication should not be used by patients with urinary retention or severe gastrointestinal disorders. Patients with myasthenia gravis, narrow-angle glaucoma, and those allergic to this medication or its ingredients should also avoid use. It is advisable that patients receiving hemodialysis or those with severe liver or kidney dysfunction do not use this medication. Additionally, it should not be administered to individuals who genetically cannot digest certain sugars. Patients at risk of urinary retention or those concerned about gastrointestinal obstruction or decreased gastrointestinal motility should use this medication cautiously. Patients with severe kidney or liver impairment should limit their dosage and be cautious when taking it with certain medications. It should also be used carefully in individuals with gastroesophageal reflux disease or autonomic neuropathy. Common side effects when taking this medication may include dry mouth, constipation, blurred vision, urinary retention, and dry eyes. Notably, dry mouth and constipation tend to occur frequently, and symptoms may worsen with higher dosages. Rarely, serious gastrointestinal-related side effects may occur, and if any unusual symptoms arise, a healthcare professional should be notified immediately. Caution is required when using this medication as drowsiness or blurred vision may impact driving or operating machinery. When taken with other anticholinergic medications, the effects may be intensified or side effects may worsen, so caution is advised. Additionally, this medication may reduce the efficacy of drugs that promote gastrointestinal motility. This medication is metabolized in the liver, so dose adjustments are necessary when taken with strong CYP3A4 inhibitors. Patients with severely impaired kidney or liver functions should avoid using such medications concurrently. The safety of this medication has not been established in pregnant women, so caution is recommended during use. Breastfeeding women should avoid using this medication due to the possibility of it passing into breast milk. The safety and efficacy of this medication in pediatric patients have not been confirmed, hence it should not be administered to children. If an overdose occurs, immediate medical attention should be sought, and appropriate treatment based on symptoms is necessary. This medication should be used with particular caution in individuals with heart disease, QT prolongation syndrome, or hypokalemia. It is important to consult a doctor or pharmacist immediately if any unusual symptoms or side effects occur during the use of this medication.

• Dry mouth
• constipation
• blurred vision
• urinary retention
• dry eyes
• fecal impaction
• colonic obstruction
• intestinal obstruction
• vascular angioedema
• nausea

This medication should be stored in a tightly closed container to prevent air or moisture from entering, and the ideal storage temperature is between 1 and 30 degrees Celsius at room temperature. Proper storage will help maintain the efficacy of the medication for a longer period and ensure safe use.

Appearance

Pink oval film-coated tablet

Package unit

28 tablets (14 tablets/PTP×2), 98 tablets (14 tablets/PTP×7)