Famcivnova Tablets 250 mg (Famciclovir)

Adult dose

1. Treatment of herpes zoster Adults: Administer 250 mg of famciclovir orally 3 times daily for 7 days. It is preferable to start treatment as soon as symptoms appear after infection. 2. Treatment of initial genital herpes infection Adults: Administer 250 mg of this drug orally 3 times daily for 5 days. It is preferable to start treatment as soon as symptoms appear after infection. 3. Treatment of acute recurrent genital herpes infection Adults: Administer 125 mg of this drug orally twice daily for 5 days. It is preferable to start treatment during the prodromal stage or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer 250 mg of this drug orally twice daily. Temporarily discontinue treatment periodically every 6～12 months to assess whether the natural course of the disease has changed. 5. Patients with renal impairment: Since the creatinine clearance of this drug is reduced in patients with renal impairment, dose adjustment should be undertaken with caution. The dosage for these patients is as follows. 1) Treatment of herpes zoster and initial genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59: 250 mg per dose twice daily Creatinine clearance (mL/min/1.73㎡) 10～29: 250 mg per dose once daily 2) Treatment of acute recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59: 125 mg per dose twice daily Creatinine clearance (mL/min/1.73㎡) 10～29: 125 mg per dose once daily 3) Suppression of recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59: 250 mg per dose twice daily Creatinine clearance (mL/min/1.73㎡) 10～29: 125 mg per dose twice daily 4) If only serum creatinine is known, creatinine clearance can be calculated using the following formula. Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis For patients undergoing hemodialysis, administration every 48 hours is preferable, taking the dialysis interval into account. Four hours of hemodialysis reduces the plasma concentration of this drug by approximately 75%; therefore, administer this drug immediately after dialysis. The recommended dose is 250 mg for patients with herpes zoster and 125 mg for patients with genital herpes. 6. Patients with hepatic impairment: No dose adjustment is necessary in patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, no clear recommended dose has been established.

This medication should not be given to certain patients. Patients who are allergic to this medication or any of its components should not use it. Additionally, because it contains lactose, patients with lactose intolerance or certain genetic metabolic disorders should not take it. Patients with impaired kidney function should be more cautious when using this medication and may need dosage adjustments. During the course of this medication, side effects such as headache, dizziness, nausea, vomiting, and skin rashes may occur, and if symptoms are severe, a consultation with a physician is recommended. Especially, elderly patients or those with kidney disease may experience central nervous system symptoms such as drowsiness or confusion more readily, so caution is advised. This medication does not completely cure genital herpes, so it is important to avoid sexual contact when symptoms are present and to maintain safe sexual practices. When driving or operating machinery, attention should be paid if dizziness or drowsiness occurs. Patients with severely impaired liver function should be cautious as the efficacy of the medication may decrease. Interactions may occur when used with other medications, so it is essential to inform healthcare professionals of any medications being taken. Women who are pregnant or breastfeeding should carefully consider the benefits and risks of using this medication, and if possible, should consult a physician before taking it. Children under 18 years of age are advised not to use it as safety and efficacy have not been established. Elderly patients generally do not need dosage adjustments, but dosage should be adjusted for those with reduced kidney function. In case of overdose, immediate medical attention should be sought for appropriate treatment, and blood dialysis may be able to reduce the drug concentration in the body. Store this medication in a sealed container that is not affected by air or moisture. Additionally, it should be stored in a cool place below 30 degrees Celsius, out of reach of children. Furthermore, transferring the medication to another container should be avoided as it can lead to accidents or degrade the quality of the drug.

• headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucinations
• palpitations

This medication should be stored in a sealed container to prevent exposure to air or moisture. It is also advisable to store it in a cool place below 30 degrees Celsius.

Appearance

White circular film-coated tablet

Package unit

21 tablets/bottle