Sameju (S-Adenosyl-L-Methionine Sulfate Tosylate)

Adult administration

Administer S-adenosyl-L-methionine 100~200mg per dose twice daily for 15~20 days by intravenous or intramuscular injection. Dissolve this medicine in the supplied diluent before use.

This medication should not be used in certain patients. Firstly, individuals who are allergic to this drug or its ingredients should avoid taking it. Patients with schizophrenia or bipolar disorder should also not use this medication. Additionally, this drug should not be taken by children, pregnant women, women who may become pregnant, or breastfeeding women. Patients with specific diseases such as homocystinuria or hyperhomocysteinemia should also avoid this medication. There may be side effects when taking this medication. Allergic reactions may cause facial swelling, tightness of the tongue and throat, difficulty breathing, rapid heartbeat, and sudden drops in blood pressure leading to shock. Gastrointestinal side effects may include occasional discomfort, nausea, vomiting, mild abdominal pain, and gastrointestinal bleeding, as well as rare occurrences of constipation, abdominal bloating, and dyspepsia. Skin reactions such as rash, itching, and hives may occur. Additionally, there may occasionally be difficulty sleeping, dry mouth, headaches, and fatigue. When administered intravenously, there may be temporary irritation, rash, or phlebitis at the injection site. In young people under 25, the risk of suicidal behavior may increase when using antidepressants like this one, so caution is advised. In individuals over 65, there is insufficient clinical data to support long-term use of this medication, thus it should be used cautiously. The safety of this medication during pregnancy has not been sufficiently established, so it is advisable not to use it. Furthermore, it is unknown whether this medication is passed through breast milk, so breastfeeding women should also avoid taking it. When given intravenously, it should be injected slowly and should not be used in conjunction with calcium salt compounds, as this can raise the pH of the drug and lead to complications. Finally, when storing or transporting this medication, do not use it if the container is cracked or discolored due to prolonged heat exposure; instead, it is safer to exchange it.

• facial edema
• rigidity of the tongue and larynx
• asthma-like respiratory distress
• tachycardia
• rapid drop in blood pressure
• shock
• gastrointestinal discomfort
• nausea
• vomiting
• mild abdominal pain

This medication must be stored in a sealed container to prevent exposure to air and kept in a refrigerated temperature between 2 to 8 degrees Celsius. This is an important storage method to maintain the drug's efficacy and prevent deterioration.

Appearance

A prescription injection containing a white powder or lump in a colorless transparent vial when dissolved for use. (Accompanying solvent: a colorless to light yellow transparent liquid in a colorless transparent ampule injection)

Package unit

5 vials/box [312 mg/vial]