Adaven Injection

Adult dosage

For adults, administer 10 mL per day if the basic daily requirement of trace elements is needed or if the daily requirement is moderately increased. This medication is diluted and administered in intravenous nutrition solutions.

Children's dosage

For children (weighing over 15 kg), administer 0.1 mL per kg of body weight per day. This medication is diluted and administered in intravenous nutrition solutions.

This medication must be diluted before use and administered exactly as directed by a physician. It should not be used in patients with hypersensitivity to this medication, bile duct obstruction, zinc toxicity, iron overload and utilization disorders, Wilson's disease, and patients with high plasma trace element levels or children weighing less than 15 kg. Patients with abnormal bile duct or kidney function, or symptoms of liver failure, and those receiving long-term intravenous nutrition must use this medication with caution and regularly check blood trace element levels. No serious adverse reactions related to trace elements have been reported; however, thrombophlebitis may occur when used with glucose injection, and allergic reactions may occur if used simultaneously with iodine-based antiseptics, so caution is advised. If used continuously for more than 4 weeks, liver function and manganese levels should be monitored, and administration should be stopped immediately if abnormalities are found. For patients with impaired kidney or liver function, there is a risk of accumulation of trace elements in the body, so regular check-ups are necessary. Hypersensitivity reactions to iron or iodine may occur, so if any symptoms of hypersensitivity appear during administration, use should be stopped immediately and appropriate treatment should be obtained. If taking iron orally at the same time, total iron intake should be regulated to prevent excess accumulation, and it is important to regularly monitor serum copper, selenium, and iron levels. When administered with iodine-containing medications, special precautions should be taken for patients with thyroid dysfunction or iodine sensitivity, and it should not be used simultaneously with iodine-based antiseptics. The safety of this medication during pregnancy has not been established; it should only be used when the therapeutic benefits outweigh the risks. Nursing mothers should discontinue breastfeeding or the use of the medication while administering this treatment. In cases of overdose, trace elements may accumulate in the body, causing issues with liver or kidney function, and in chronic iron overload patients, serum iron accumulation may worsen, so caution is needed. This medication can be added to intravenous nutrition solutions, such as glucose injection, but should not be used with solutions that have incompatibility risks. It is safest to handle and use the diluted solution immediately while ensuring aseptic techniques. Diluted solutions are stable at room temperature for 24 hours; however, to prevent microbial contamination, they should be used immediately or stored at 2-8 degrees Celsius and used within 24 hours, and any remaining solution should be discarded.

Serious side effects

• Urticaria
• severe swelling (edema)
• difficulty breathing
• cold sweat
• pallor
• severe allergic reactions
• severe rashes accompanied by high fever
• blisters
• skin peeling
• pain in oral/ocular mucous membranes

Mild side effects

• Superficial thrombophlebitis
• hypersensitivity reactions
• liver dysfunction
• increased manganese levels
• risk of trace element accumulation
• anaphylaxis reactions
• iron overload
• hemosiderosis
• risk of compatibility issues

This medication should be stored in a sealed container to prevent air or moisture from entering, and the storage temperature should be between 1 and 25 degrees Celsius in a cool place. Proper storage helps maintain the medication's effectiveness for a longer duration.

Appearance

An injection containing a nearly colorless and transparent solution in a clear plastic ampoule

Package unit

10 mL/ampoule X 20