Hawon Meropenem Injection 1g (Meropenem Hydrate)

Adult administration

As Meropenem hydrate, the dosage is administered by intravenous drip at 0.5 to 1 g (potency) daily in 2 to 3 divided doses over at least 30 minutes. For suspected infections in patients with pathogenic pneumonia, peritonitis, or neutropenia, 1 g (potency) is administered by intravenous drip every 8 hours. For cystic fibrosis and meningitis, 2 g (potency) is administered by intravenous drip every 8 hours.

Child administration

For bacterial meningitis in children over 3 months of age, the dosage is administered by intravenous drip at 40 mg per kg of body weight every 8 hours over at least 30 minutes, depending on the pathogen's sensitivity and the patient's status and type of infection. Severe cases

This drug should not be used in patients who have experienced shock due to this medication in the past. Additionally, patients taking valproate sodium should avoid using this drug, as it may lower blood valproate levels and increase the risk of seizure recurrence. Patients with known allergies to this drug or its components, a history of hypersensitivity reactions, and those who have had severe allergic reactions to other carbapenem or beta-lactam antibiotics should also not be administered this medication. Patients with allergic predispositions or those with a history of allergic reactions such as bronchial asthma or skin rashes should use this drug cautiously, and patients with impaired kidney function may require dose adjustments as the medication may remain in the body longer, leading to CNS symptoms. Patients with a history of seizures or CNS disorders, severely compromised liver function, elderly patients, and malnourished individuals, as well as infants under 3 months, should also be given careful consideration. This drug can rarely cause severe allergic reactions such as shock, anaphylaxis, rashes, and urticaria, so patients’ conditions should be closely monitored during administration. Blood tests may show leukopenia, anemia, and platelet abnormalities, necessitating regular blood testing. Monitoring liver and kidney function is also important. If severe diarrhea or abdominal pain occurs, there may be a risk of severe colitis such as pseudomembranous colitis, and medical personnel should be notified immediately. If CNS symptoms such as seizures or consciousness disturbances appear, administration should be stopped immediately and appropriate treatment obtained. Various side effects have been reported, including respiratory, skin, cardiovascular, and psychiatric effects, so medical consultation should be sought quickly if any abnormal symptoms occur. This drug should only be used for the minimum duration required to prevent antibiotic resistance, and it is important to confirm the sensitivity of pathogens before and during treatment. A previous history of severe allergic reactions to beta-lactam drugs such as penicillins or cephalosporins must be confirmed. During administration of this drug, headaches, dizziness, and confusion may occur, so caution is required when driving or operating machinery. If symptoms such as muscle pain, muscle weakness, or dark urine appear, there may be a risk of rhabdomyolysis, and medical personnel should be informed immediately. This drug interacts with some medications, potentially changing their concentrations, so inform healthcare providers if taking other medications. Women who are pregnant or could become pregnant should use this drug cautiously, and breastfeeding should be avoided during treatment. Its safety and efficacy have not been established in infants under 3 months, so its use is not recommended. Elderly patients may have a higher risk of side effects due to decreased body function, so careful adjustments of dosage and intervals are necessary. This drug should be used as soon as possible after reconstitution and should only be given via intravenous injection. Finally, this drug may have cross-reactivity with other beta-lactam antibiotics, so previous drug responses should be discussed with the healthcare provider.

Serious side effects

Shock, anaphylaxis, urticaria, angioedema, severe skin reactions, severe rashes, blisters, skin shedding, pain in mucous membranes of the mouth/eyes, asthma attacks, respiratory distress, breathing problems, jaundice, liver failure, liver abnormalities, sudden and severe headaches, seizures, confusion, visual disturbances, paralysis, convulsions, severe swelling, urinary abnormalities, acute kidney failure, severe kidney damage, pseudomembranous colitis, toxic epidermal necrolysis (Lyell syndrome), bleeding

Mild side effects

• Discomfort
• oral abnormalities
• wheezing
• dizziness
• stool changes
• tinnitus
• sweating
• rash
• urticaria
• heat sensation

This medication should be stored in a sealed container to protect it from air exposure, and the storage temperature should be maintained between 1 degree and 30 degrees Celsius room temperature. Storing this way helps to maintain the drug's effectiveness for a longer period.

Appearance

A white to light yellow crystalline powder in a colorless and transparent vial for injection

Package unit

10 vials/box