Hybric Tablet 80 Milligrams (Febuxostat)

Adult dosage

Administer 40mg or 80mg once daily. This medicine acts very rapidly, so recheck the serum uric acid concentration after 2 weeks. The treatment goal is to lower and maintain the serum uric acid concentration at less than 6 mg/dL(357 μmol/L). No dose adjustment is necessary in patients with mild or moderate renal impairment. The safety and efficacy of this medicine have not been adequately evaluated in patients with severe renal impairment (creatinine clearance less than 30mL/min). No special dose adjustment is necessary in patients with mild or moderate hepatic impairment. Only limited information is available for patients with moderate hepatic impairment, and the efficacy and safety of this medicine have not been studied in patients with severe hepatic impairment (Child Pugh class C).

This medication may increase cardiovascular mortality in patients with cardiovascular diseases, so its administration should be carefully considered in such patients. It should not be administered to patients with allergies to the active ingredient or excipients, those taking mercaptopurine or azathioprine, and those with certain genetic lactose metabolism abnormalities. Patients with a history of liver disease or thyroid dysfunction, ischemic heart disease, heart failure, and those taking theophylline should have their liver function monitored periodically during treatment with this medication. While taking this medication, various side effects such as liver function abnormality, diarrhea, headache, rash, fatigue, and dizziness may occur, and if symptoms appear, consultation with a physician should be sought immediately. This medication should not be started during an acute gout attack, and an increase in gout attacks may occur temporarily at the beginning of treatment, requiring preventive medication with NSAIDs or colchicine. This medication may cause drowsiness, dizziness, or decreased sensation, so caution should be exercised during activities like driving or operating machinery. Severe allergic reactions, such as Stevens-Johnson syndrome or anaphylaxis, may occur, and if such symptoms appear, discontinuation and visit to a medical institution are necessary. Pregnant or breastfeeding women are advised not to take this medication, and it is not to be used in children or adolescents under 18 due to insufficient experience.</n> This medication may interact with other drugs, so caution is required, especially when used in combination with mercaptopurine, azathioprine, theophylline, or naproxen. In case of overdose, there is no specific antidote, and symptomatic treatment should be provided; it should be stored out of reach of children.

Liver dysfunction, dizziness, diarrhea, headache, rash, nausea, fatigue, joint pain, limb pain, gout, myalgia, pruritus, dyspnea, vomiting, joint pain, rash, anemia, idiopathic thrombocytopenic purpura, leukocytosis, leukopenia, neutropenia, pancytopenia, splenomegaly, thrombocytopenia, angina, atrial fibrillation, atrial flutter, heart murmur, abnormal electrocardiogram, palpitations, bradycardia, tachycardia, hearing loss, tinnitus, vertigo, blurred vision, abdominal distension, abdominal pain, constipation, dry mouth, dyspepsia, bloating, increased bowel frequency, gastritis, gastroesophageal reflux disease, gastrointestinal discomfort, gum pain, hematemesis, excessive hydrochloric acid, hematochezia, oral ulcer, pancreatitis, gastric ulcer, vomiting, weakness, chest pain, chest discomfort, edema, mood changes, walking difficulties, influenza-like symptoms, pain, thirst, cholelithiasis, diabetes mellitus, fatty liver, hepatitis, hepatomegaly, hypersensitivity, shingles, loss of appetite, decreased appetite, increased appetite, dehydration, diabetes, hypercholesterolemia, hyperlipidemia, hypertriglyceridemia, hypokalemia, weight loss, weight gain, arthritis, joint stiffness, joint swelling, muscle cramps, muscle fasciculation, muscle rigidity, muscular weakness, musculoskeletal pain, muscle tone increase, taste changes, balance abnormalities, cerebrovascular accident, Guillain-Barré syndrome, headache, incomplete paralysis, sensory loss, olfactory reduction, cerebral infarction, drowsiness, mental disorders, migraine, sensory disturbances, somnolence, transient ischemic attack, tremors, agitation, anxiety, depression, insomnia, excitability, decreased libido, irritability, panic attacks, personality changes, hematuria, nephrolithiasis, frequent urination, proteinuria, renal failure, renal insufficiency, urinary urgency, urinary incontinence, mastalgia, erectile dysfunction, gynecomastia, bronchitis, cough, dyspnea, epistaxis, nasal dryness, sinus hypersecretion, pharyngeal edema, airway congestion, sneezing, throat irritation, upper respiratory infection, alopecia, angioedema, dermatitis, skin necrosis, petechiae, eczema, hair discoloration, abnormal hair growth, hyperhidrosis, skin peeling, petechiae, photosensitivity, pruritus, purpura, skin pigmentation changes, skin lesions, axillary hyperhidrosis, urticaria, flushing, facial flushing, hypertension, hypotension, prolonged activated partial thromboplastin time, increased creatinine, decreased bicarbonate, increased sodium, abnormal EEG, increased glucose, increased cholesterol, increased triglycerides, increased amylase, increased potassium, increased thyroid-stimulating hormone, decreased platelets, decreased hematocrit, decreased hemoglobin, increased MCV, decreased red blood cells, increased creatinine, increased blood urea nitrogen, increased blood urea nitrogen to creatinine ratio, increased CPK, increased ALP, increased LDH, increased PSA, increased urine output, decreased urine output, decreased lymphocyte count, decreased neutrophil count, increased leukocyte count, decreased leukocyte count, abnormal coagulation tests, increased low-density lipoprotein, prolonged prothrombin time, urinary casts, positive urinary leukocytes, positive urinary protein, contusions, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute anaphylactic reaction, shock, eosinophilia, systemic symptoms, drug reaction DRESS, liver failure, jaundice, hepatic impairment, agranulocytosis, rhabdomyolysis

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture, and it is best to keep it at room temperature between 1 and 30 degrees Celsius. This will help maintain the medication's effectiveness.

Appearance

Light yellow to yellow, oblong film-coated tablets with a dividing line on one side.

Package unit

28 tablets/bottle