Zocona Tablet 20 mg (Simvastatin)

Adult dose

For reduction of cardiovascular disease risk: The recommended initial starting dose is 40 mg once daily. For hyperlipidemia: The usual recommended initial starting dose is 20 mg once daily in the evening. Patients with mild to moderate hypercholesterolemia can start with 10 mg, and 5–40 mg may be given once daily in the evening. Prior to administration, initial LDL cholesterol levels, target treatment levels, and the patient's drug response should be considered for dosage adjustment.

Child dose

Pediatric patients (10–17 years) with heterozygous familial hypercholesterolemia: The recommended initial dose is 10 mg once daily in the evening. The recommended dosage range is 10–40 mg per day, with a maximum dose of 40 mg.

This medication can cause serious muscle-related side effects such as myopathy and rhabdomyolysis, especially when taken in high doses. Therefore, patients taking high doses are recommended to use other medications with fewer drug interactions or a lower dose. Patients with allergies to this medication, those with liver disease, women who are pregnant or breastfeeding, or those taking specific powerful medications should not take this medication. Alcoholics or patients with poor liver or kidney function, those with hypothyroidism or history of muscle disease should use this medication with great caution. If symptoms such as muscle pain, muscle weakness, or unexplained muscle symptoms occur while taking this medication, inform your doctor immediately and discontinue the medication if necessary. Liver function abnormalities may occur, so regular liver function tests should be conducted, and treatment should be stopped if any abnormalities are noted. This medication can interact with various drugs; therefore, anyone taking other medications should inform their doctor or pharmacist. In particular, the risk of myopathy may be increased when used in conjunction with certain antifungals, antibiotics, immunosuppressants, and calcium channel blockers. Women who are pregnant or may become pregnant should not take this medication and should discontinue it immediately if pregnancy is confirmed. Breastfeeding women should also stop breastfeeding if taking this medication. This medication is not used in children under 10 years old or premenarchal girls. Elderly patients, especially those aged 65 and older, should take extra caution as they are at a higher risk for myopathy while using this medication. It is advisable to avoid grapefruit juice while taking this medication, and if an overdose occurs, seek medical help immediately. This medication should be kept out of reach of children and stored in its original container for safety.

Serious side effects

Myopathy/rhabdomyolysis, hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, pallor, severe rash with fever, blisters, skin peeling, pain in mucous membranes of mouth/eyes, difficulty breathing or shortness of breath, asthma attacks, respiratory abnormalities accompanied by cough and fever, jaundice (yellowing of skin or eyes), extreme lethargy, sudden and very severe headache, thunderclap headache, seizures, confusion of consciousness, visual disturbances

Mild side effects

Abdominal pain, weakness, constipation, diarrhea, indigestion, bloating, nausea, headache, upper respiratory infection, atrial fibrillation, gastritis, diabetes, muscle pain, insomnia, dizziness, bronchitis, sinusitis, eczema, urinary tract infection, alopecia, pruritus, various skin changes, drug rash resembling lichen planus, gynecomastia, decreased libido, sexual dysfunction, cataract progression, ocular muscle paralysis, anemia, thyroid function abnormalities, temporary and mild liver function tests abnormalities, H

This medication should be stored in a tightly sealed container to prevent air entry, at room temperature between 1°C to 30°C. Storing it this way will help maintain the drug's effectiveness for a longer period.

Appearance

Brown oval film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle