Ilseong Ceftriaxone Injection 500mg (Ceftriaxone Sodium Hydrate)

Adult administration

Adults and children over 12 years should receive 1-2g (potency) of ceftriaxone via intravenous or intramuscular injection once daily. In cases of infections caused by pathogens exhibiting severe disease or moderate sensitivity, the dosage can be increased to 4g (potency) once daily. Elderly patients do not require a change in the adult dosage regimen. For gonorrhea treatment, a single intramuscular injection of 250mg (potency) is recommended. For preventing infections before and after surgery, the treatment should be based on the infection risk.

Child administration

Newborns (within 14 days of birth) should receive 20-50mg/kg (potency) once daily, without exceeding 50mg/kg (potency). Infants and children (from 15 days to 12 years) should be given dosage based on body weight.

This drug should never be administered together with calcium-containing solutions as it can lead to precipitation and serious side effects. In particular, administering this medication with calcium-containing solutions in newborns is extremely dangerous, and should be avoided. Patients who have allergies to this medication or have had hypersensitivity reactions to similar classes of antibiotics should not use it. This drug is also contraindicated for premature infants or newborns with jaundice, hypoalbuminemia, or acidosis, as it may cause bilirubin encephalopathy. Patients with very poor kidney function or a history of drug allergies should exercise caution when using this medication and may require dosage adjustments as necessary. Regular blood tests, liver function tests, and kidney function tests should be conducted while using this drug to detect any adverse reactions at an early stage. If allergic symptoms such as rash, urticaria, difficulty breathing, or dizziness occur during administration, the treatment should be immediately discontinued, and appropriate treatment should be provided. This drug can cause side effects such as diarrhea, vomiting, increased liver enzymes, and reduction in blood cells, so careful observation is required. Elderly patients or those in poor overall condition are at risk of bleeding, so vitamin K levels should be monitored and supplemented if needed. Women who are pregnant or breastfeeding should consult with a doctor, as the administration of this drug may affect the fetus or infant. Caution is also necessary as this drug may increase the risk of accidents due to dizziness during driving or operating machinery. Rarely, severe colitis may occur after antibiotic use, so if diarrhea persists, the healthcare provider must be notified immediately. Furthermore, this drug may interact with other medications, so any concurrent medications should be disclosed. During intravenous administration, pain or inflammation may occur at the injection site, so care should be taken regarding the injection method and speed. There is no specific antidote for overdose of this drug, so symptomatic treatment should be received. It is important to confirm the sensitivity of infection-causing bacteria and use this drug only for the required duration to prevent the development of antibiotic-resistant strains.

Serious side effects

Urticaria, severe swelling (edema), anaphylaxis and anaphylactoid reactions, severe allergic reactions, severe skin adverse reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis), severe swelling or abnormalities in urination (acute renal failure, oliguria), liver abnormalities (jaundice, elevated bilirubin, kernicterus), severe neurological symptoms (encephalopathy, seizures, confusion, myoclonus, non-convulsive status epilepticus), respiratory issues (dyspnea,

Mild side effects

Eosinophilia, leukopenia, thrombocytopenia, diarrhea, rash, increased liver enzymes, headache, dizziness, bronchospasm, loose stools, nausea, vomiting, itching, hematuria, diabetes, phlebitis, injection site pain, fever, edema, chills, increased serum creatinine, stomatitis, candidiasis, symptoms of vitamin K deficiency, symptoms of vitamin B group deficiency, ventricular ectopic beats, sweating, flushing, palpitations, nosebleed, Clostridium difficile-associated diarrhea, hypotension

This medication should be stored in a sealed container to protect it from air and moisture. It is recommended to maintain a storage temperature between 1 to 30 degrees Celsius to prolong the effectiveness of the drug.

Appearance

A white to light yellow crystalline powder filled in a colorless, transparent vial

Package unit

500mg/vial X 10 vials/box