Hybimadol Injection (Tramadol Hydrochloride)

Adult administration

As Tramadol Hydrochloride, administer 50-100 mg intravenously or intramuscularly once, repeated every 4-5 hours as needed. The maximum daily dose is 400 mg.

This medication may cause seizures if taken in doses exceeding the recommended amount, so caution is required. It should only be used when necessary, especially in patients with a risk of epilepsy or seizures. Long-term use may lead to psychological and physical dependence, so it should be used for a limited time and under strict supervision in patients with a history of drug abuse or dependence. Taking this drug with alcohol or central nervous system depressants may pose a risk of severe sedation, respiratory depression, coma, or death; therefore, it should be avoided or administered with caution. Individuals genetically predisposed to metabolize this drug rapidly may have higher concentrations of the active ingredient, increasing the risk of respiratory depression; thus, dose adjustment and monitoring are essential. This drug should not be administered to children under 12 years or adolescents who have undergone tonsillectomy or adenoidectomy, and caution is recommended in adolescents aged 12 to under 18 years who are at risk. It should not be used in cases of acute alcohol intoxication, CNS drug overdose, severe respiratory depression, head injury, recent use of MAO inhibitors, severe liver or kidney impairment, and pregnant or nursing women. Caution is required when used in combination with morphine or in patients with liver disease, biliary disorders, or those who consume alcohol, as there is a risk of seizures in patients with a history of seizures. This medication may cause side effects such as drowsiness, dizziness, nausea, and vomiting; therefore, it is safer to avoid driving or operating hazardous machinery after taking it. Long-term use may develop tolerance, requiring increased dosages, and sudden discontinuation may lead to withdrawal symptoms; thus, it should be tapered gradually. This medication may interact with various other drugs; therefore, particularly when used in combination with central nervous system depressants, antidepressants, anticoagulants, etc., strict adherence to the physician's instructions is required. Pregnant or nursing women should not take this medication, as severe side effects may occur in the baby during nursing. In the case of overdose, severe respiratory depression and seizures may occur, requiring immediate emergency treatment, and antidotes such as naloxone may be used. This drug should be stored out of the reach of children and kept in its original container to prevent misuse or deterioration.

Serious side effects

Hives, shock, anaphylaxis, bronchospasm, angioedema, severe allergic reactions, severe seizures, convulsions, respiratory depression, difficulty breathing, worsening of asthma, life-threatening respiratory depression, increased liver enzyme levels, liver abnormalities (although jaundice symptoms have not been specified, classified as cholestasis), Stevens-Johnson syndrome, severe headache, coma, altered consciousness, loss of consciousness, increased blood pressure, cardiovascular abnormalities (edema associated with severe swelling or urinary disturbances)

Mild side effects

• Drowsiness
• dizziness
• lightheadedness
• nausea
• vomiting
• abdominal distension
• abdominal discomfort
• abdominal pain
• loss of appetite
• constipation

This medication should be stored in a sealed container at a temperature between 1 and 30 degrees Celsius. Proper storage will maintain the drug's efficacy.

Appearance

A colorless, transparent ampule containing a colorless liquid

Package unit

1ml x 50 ampules/Box