Febuxostat 80 mg (Febuxostat)

Adult dosage

1. Adults This medicine is administered at 40mg or 80mg once daily, regardless of meals. This medicine acts very rapidly; recheck serum uric acid levels after 2 weeks. The treatment goal is to lower and maintain serum uric acid levels below 6 mg/dL(357 μmol/L). 2. Patients with renal impairment No dose adjustment is necessary in patients with mild or moderate renal impairment. The safety and efficacy of this medicine have not been adequately evaluated in patients with severe renal impairment (creatinine clearance below 30mL/min). 3. Patients with hepatic impairment No special dose adjustment is necessary in patients with mild or moderate hepatic impairment. Only limited information is available for patients with moderate hepatic impairment, and the efficacy and safety of this medicine have not been studied in patients with severe hepatic impairment (Child Pugh class C).

This medication may increase the risk of cardiovascular mortality in patients with cardiovascular diseases; thus, patients with a history of major cardiovascular diseases such as myocardial infarction, stroke, or unstable angina should consider alternative treatments. Patients allergic to the active ingredient or excipients in this medication, patients taking mercaptopurine or azathioprine, and patients with certain genetic lactose intolerance conditions should not take this medication. Patients with a history of liver disease should undergo regular liver function tests while taking this medication, and patients with changes in thyroid function should also take caution. Patients with ischemic heart disease, congestive heart failure, and organ transplant recipients should use this medication carefully. When taking this medication with theophylline, caution is advised due to insufficient information on long-term safety due to increased metabolites. Common side effects during the use of this medication may include liver dysfunction, diarrhea, headache, rash, fatigue, arthralgia, dizziness, and so on. If there is a sudden deterioration in liver function, discontinue use immediately and consult a physician. During an acute gout attack, it is recommended not to start this medication and to continue non-steroidal anti-inflammatory drugs or colchicine for at least 6 months to prevent gout exacerbation. This medication may cause drowsiness, dizziness, or sensory impairment; therefore, caution is needed when driving or operating machinery. If cardiovascular symptoms or unusual signs appear, consult medical personnel immediately, and if a severe allergic reaction occurs, discontinue use immediately. It is advisable for pregnant or breastfeeding women to avoid taking this medication, and it is not recommended for children under 18 years of age. In case of overdose, there is no specific antidote, and treatment should be symptomatic, keeping this medication out of reach of children.

Liver dysfunction, dizziness, diarrhea, headache, rash, nausea, fatigue, arthralgia, limb pain, gout, myalgia, pruritus, dyspnea, anemia, idiopathic thrombocytopenic purpura, leukocytosis, leukopenia, neutropenia, pancytopenia, splenomegaly, thrombocytopenia, angina, atrial fibrillation, atrial flutter, heart murmur, abnormal ECG, palpitations, bradycardia, tachycardia, hearing loss, tinnitus, vertigo, blurred vision, abdominal distension, abdominal pain, constipation, dry mouth, indigestion, bloating, increased bowel movements, gastritis, gastroesophageal reflux disease, gastrointestinal discomfort, gum pain, hematemesis, hyperchlorhydria, passage of blood in stool, oral ulcer, pancreatitis, gastric ulcer, vomiting, weakness, chest pain, chest discomfort, edema, mood disturbances, gait disturbances, influenza-like symptoms, mass, pain, thirst, cholelithiasis, diabetes mellitus, fatty liver, hepatitis, hepatomegaly, hypersensitivity, herpes zoster, loss of appetite, decreased appetite, increased appetite, dehydration, diabetes, hypercholesterolemia, hyperlipidemia, hypertriglyceridemia, hypokalemia, weight loss, weight gain, arthritis, joint stiffness, joint swelling, muscle cramps, single muscle contraction, muscle constriction, muscle weakness, musculoskeletal pain, muscle rigidity, altered taste, balance disturbances, cerebrovascular accident, Guillain-Barré syndrome, headache, incomplete paralysis, sensory loss, decreased sense of smell, cerebral infarction, drowsiness, mental disorders, migraine, sensory disturbances, somnolence, transient ischemic attack, tremors, agitation, anxiety, depression, insomnia, excitability, decreased libido, nervous hyperactivity, panic attacks, personality changes, hematuria, nephrolithiasis, frequent urination, proteinuria, renal failure, renal insufficiency, urgency, urinary incontinence, breast pain, erectile dysfunction, gynecomastia, bronchitis, cough, dyspnea, epistaxis, nasal dryness, excessive sinus secretion, pharyngeal edema, airway congestion, sneezing, throat irritation, upper respiratory infection, alopecia, vascular edema, dermatitis, skin rash, petechiae, eczema, hair discoloration, abnormal hair growth, hyperhidrosis, skin peeling, petechiae, photosensitivity, pruritus, purpura, skin discoloration, changes in pigmentation, skin lesions, axillary hyperhidrosis, urticaria, flushing, facial flushing, hypertension, hypotension, activated partial thromboplastin time prolongation, creatinine increase, bicarbonate decrease, sodium increase, abnormal EEG, glucose increase, cholesterol increase, triglyceride increase, amylase increase, potassium increase, thyroid-stimulating hormone increase, platelet decrease, hematocrit decrease, hemoglobin decrease, increased MCV, erythrocyte decrease, creatinine increase, blood urea increase, blood urea creatinine ratio increase, CPK increase, ALP increase, LDH increase, PSA increase, urine output increase, urine output decrease, lymphocyte count decrease, neutrophil count decrease, leukocyte count increase, leukocyte count decrease, abnormal coagulation test, low-density lipoprotein increase, prothrombin time prolongation, urine casts, positive urinary leukocytes, positive urinary protein, contusions, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute anaphylactic reaction, shock, severe allergic reactions, hypersensitivity reactions, liver failure, jaundice, liver dysfunction, agranulocytosis, rhabdomyolysis

This medication should be stored in a tightly closed container to prevent air or moisture from entering, and it is best to keep it at room temperature between 1 and 30 degrees Celsius. This will help maintain the medication's effectiveness for a long time.

Appearance

Pale yellow to yellow rectangular film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle