Kementin Tablet 625 mg (Amoxicillin and Clavulanate Potassium)

Adult dose

Adults and children 12 years of age or older or weighing 40 kg or more should take amoxicillin/clavulanate potassium as a single dose of 250 mg/125 mg, orally three times a day every 8 hours. In severe and respiratory infections, the dose may be increased to 500 mg/125 mg per single dose. For those with renal impairment, dosing should be adjusted according to creatinine clearance. - Creatinine clearance 10 to 30 mL/min: 250 to 500 mg of amoxicillin per single dose every 12 hours.

Child dose

For children under 12 years or weighing less than 40 kg, dosage should be reduced accordingly in cases of renal impairment.

This medicine is a beta-lactam antibiotic and should not be used in patients with a history of allergic reactions to penicillin group drugs. Particularly, individuals with a history of anaphylaxis, Stevens-Johnson syndrome, or shock should avoid administration. Patients with infectious mononucleosis or lymphocytic leukemia should be cautious due to the increased risk of rash. It is also advisable not to use this medicine in individuals with a history of liver dysfunction or jaundice caused by this drug or penicillin group drugs. Patients with poor liver function should be cautious as the drug may burden the liver. For patients with moderate to severe renal impairment, dosing intervals should be adjusted as drug concentration may increase. Individuals with an allergic constitution or family history should inform their healthcare provider before administration, and elderly patients or those in poor overall condition who are at risk of vitamin K deficiency should also take caution. Patients exhibiting gastrointestinal symptoms such as vomiting or diarrhea should be closely monitored as the absorption of the drug may be insufficient. When taking this medication, gastrointestinal adverse reactions such as diarrhea, abdominal pain, and vomiting may occur; in severe cases, severe colitis such as pseudomembranous colitis may develop, so if symptoms worsen, immediate cessation and consultation with a healthcare provider is advised. Liver function abnormalities may arise, thus regular monitoring of liver function tests during and after treatment is important. Should skin rash, itching, or severe allergic reactions occur, administration of the medication should be immediately stopped and healthcare instructions followed. Though rare, blood abnormalities such as leukopenia, thrombocytopenia, and anemia can occur, so regular blood tests are necessary. Central nervous system disturbances such as anxiety, confusion, and seizures have been reported rarely, especially in patients with renal impairment or those treated with high doses. This medication is excreted via the kidneys, thus those with kidney dysfunction may require dosage adjustments, and regular kidney function tests are advised. The use of antibiotics may disrupt intestinal bacterial balance, leading to fungal infections such as candidiasis, so symptoms should be reported if they arise. There may be a tendency for bleeding due to vitamin K deficiency, thus caution is required during long-term administration. This medicine may interact with other medications, so if the patient is currently taking any other drugs, it is essential to inform the healthcare provider, especially when used with anticoagulants, diuretics, or drugs for gout. It should be avoided during pregnancy, particularly in the first three months, and caution should be exercised during lactation as adverse reactions may occur in the infant. Not recommended for children, particularly those under 12 years or weighing less than 40 kg. The elderly should be cautious due to the increased risk of adverse reactions related to impaired renal and liver function, requiring careful adjustment of dosage and administration intervals. Symptoms of overdose may include vomiting, diarrhea, abdominal pain, drowsiness, and seizures, necessitating immediate medical attention. This medicine should be stored in a sealed container to prevent moisture and kept in a cool, dry place, especially ensuring temperatures remain below 25 degrees Celsius.

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, cold sweats, paleness, severe allergic reactions (including anaphylaxis and shock), high fever accompanied by severe rash, blisters, skin peeling, pain in the oral/ocular mucosa, severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, Lyell's syndrome), feeling short of breath or difficulty breathing, asthma attacks, respiratory issues with cough and fever, jaundice, symptoms indicating liver abnormalities (skin manifestations)

Mild side effects

Diarrhea, indigestion, stomatitis, gastritis, glossitis, nausea, vomiting, loss of appetite, abdominal pain, abdominal bloating, constipation, colicky pain, hypersensitivity, mouth dryness, acute pancreatitis, candidiasis, antibiotic-associated colitis, bloody stools, itching, erythema multiforme, dermatitis, generalized pustular rash, angioedema, serum sickness, hypersensitivity vasculitis, blood abnormalities (leukopenia, thrombocytopenia, hemolytic anemia, anemia, thrombocytosis, bone pain)

This medicine should be stored in a sealed container to prevent moisture and kept in a cool, dry place. Maintaining a temperature below 25 degrees Celsius is especially important.

Appearance

This medicine is a white or almost white oval film-coated tablet.

Package unit

40 tablets (4 tablets/PTP*10)