Neotrace 4 Weeks (Pediatric)

Adult administration

Use as prescribed by a physician, checking plasma trace element levels to guide dosage adjustments.

Child administration

Permissible dosage range for infants and children (for intravenous use): 1. Zinc - Infants under 5 years: 100㎍ per kg of body weight daily - Premature infants weighing 3 kg or less: 300㎍ per kg of body weight daily 2. Copper -

This medication should never be administered by direct injection into the vein without dilution, as it may cause inflammation of the blood vessels. This medication is a low-osmolarity solution and should only be used when mixed with other medications for injection. If any component among the active ingredients shows toxicity, administration must be stopped immediately. The aluminum content in this medication may be harmful, particularly to premature infants or patients with impaired kidney function, when administered over prolonged periods. The amounts of zinc, copper, manganese, and chromium included in this medication are very small, so toxic symptoms generally do not occur. Prior to injection, the physician should accurately assess the patient's health status and the required mineral amount to determine the appropriate dosage, and blood trace element levels should be monitored frequently. Zinc is mainly excreted through the intestines and kidneys, so patients with reduced kidney function may accumulate zinc in the body. Copper and manganese are excreted through bile, so patients with bile duct obstruction may be at risk of accumulating these components. Manganese may be reabsorbed from pancreatic and some intestinal secretions, thus having various excretion pathways. Chromium is primarily excreted by the kidneys and may affect blood glucose regulation, so patients with diabetes should consult a physician before use. There is insufficient research on the safety of this medication during pregnancy; therefore, it should only be used when necessary and according to a physician's instructions. In cases of overdose, zinc may cause symptoms such as sweating, altered consciousness, blurred vision, rapid heartbeat, and hypothermia, and in severe cases, may lead to death. Excessive intake of copper can cause symptoms such as weakness, behavioral changes, diarrhea, muscle hypotonia, and edema, for which D-penicillamine is used as an antidote. Manganese toxicity has not been reported when this medication is used at the prescribed dosage, and excessive intake from food sources is also uncommon. In case of chromium overdose, symptoms such as nausea, vomiting, gastrointestinal disturbances, kidney and liver damage, and central nervous system abnormalities may occur. This medication should not be used without a prescription, and it is important to maintain a sterile condition during administration. The solution is acidic; therefore, aluminum needles or connectors should not be used. Before administration, ensure that the solution has not changed color or that particles are not floating. The trace elements contained in this medication can be safely used together with electrolytes or vitamins found in other non-oral nutritional fluids. Keep this medicine out of the reach of children, and transferring it to another container is not advisable to maintain quality and safety.

Serious side effects

• Jaundice
• altered consciousness
• visual disturbances
• paralysis
• pulmonary edema
• decreased urine output

Mild side effects

• Sweating
• decreased consciousness
• blurred vision
• tachycardia
• hypothermia
• diarrhea
• vomiting
• weakness
• behavioral changes
• diarrhea

Store this medication in a sealed container to prevent air or moisture from entering, and keep it at room temperature between 15 to 30 degrees Celsius. This will help maintain the efficacy of the medication for a longer period.

Appearance

A colorless or slightly blue, odorless, transparent solution filled in a colorless transparent vial.

Package unit

10 vials/box [(2mL/vial)]