Medication info
Combirucan Tablet 5/8 mg

Combirucan Tablet 5/8 mg

Prescription medicationTablet경구
Ingredient · strength
Rosuvastatin Calcium›5.2mg / 1 tabletCandesartan Cilexetil›8mg / 1 tablet
Manufacturer / importer
환인제약(주)
Appearance
Pink round film-coated tablets
Packaging
30 tablets (10 tablets/PTP X 3)
Approval status
Active

MFDS item code 201702403 · Approved 2017.05.16 · Insurance code 657203090

Summary

Main use
(Hypertension, heart failure) improvement and (hypercholesterolemia, cardiovascular disease risk) inhibition
Who takes it
Adults · Children
Adult dose
Candesartan Cilexetil for essential hypertension: the initial and maintenance dose is recommended as 8-16 mg orally once daily. If blood pressure is not adequately controlled, the dose may be increased to a maximum of 32 mg once daily. Heart failure: initial dose of 4 mg once daily, increased by doubling the dose at intervals of 2 weeks or more, with a maximum of 32 mg once daily. Rosuvastatin: initial dose of 5 mg once daily.
Child dose
Safety and efficacy in adolescents and children under 18 years of age have not been established.

Ingredients

Manufacturer
환인제약(주)

Efficacy & effects

(Hypertension, heart failure) improvement and (hypercholesterolemia, cardiovascular disease risk) inhibition

  • Essential hypertension
  • left ventricular systolic dysfunction
  • hypercholesterolemia
  • heterozygous familial hypercholesterolemia
  • mixed hyperlipidemia
  • homozygous familial hypercholesterolemia
  • dysbetalipoproteinemia
  • elevated high-sensitivity C-reactive protein
  • hypertension
  • low HDL cholesterol
  • smoking
  • family history of early coronary artery disease
View approved original text

This medication is prescribed for patients who require the simultaneous use of two drugs, Candesartan Cilexetil and Rosuvastatin. Candesartan Cilexetil helps control blood pressure and is used in patients with essential hypertension and heart failure with left ventricular systolic dysfunction. It is particularly effective when treatment with ACE inhibitors is insufficient or poorly tolerated. Rosuvastatin is mainly used for hypercholesterolemia and the prevention of atherosclerosis, helping patients with hyperlipidemia that is not controlled by diet. It also contributes to the reduction of the risk of stroke, myocardial infarction, and vascular reintervention in patients at high risk of cardiovascular disease. Therefore, this medication is used to simultaneously improve hypertension, hyperlipidemia, and the risk of cardiovascular disease.

How to take

Adult dose

Candesartan Cilexetil for essential hypertension: the initial and maintenance dose is recommended as 8-16 mg orally once daily. If blood pressure is not adequately controlled, the dose may be increased to a maximum of 32 mg once daily. Heart failure: initial dose of 4 mg once daily, increased by doubling the dose at intervals of 2 weeks or more, with a maximum of 32 mg once daily. Rosuvastatin: initial dose of 5 mg once daily.

Child dose

Safety and efficacy in adolescents and children under 18 years of age have not been established.

Precautions

This medication can cause serious harm to the fetus and newborn, especially during pregnancy, so it should be discontinued immediately upon confirmation of pregnancy. Patients with allergies to this drug, liver disease, severe liver dysfunction, renal failure, and myopathy should not take this medication. Women of childbearing potential should only take this medication if they fully understand the possibility of pregnancy and risks to the fetus, and should use appropriate contraceptive methods. Elderly patients or those with liver dysfunction, renal dysfunction, or hyperkalemia should use this medication carefully, and regular blood tests and liver function tests may be required during treatment. This medication may cause muscle-related side effects such as myalgia, myopathy, and rhabdomyolysis; if unexplained muscle pain or weakness occurs during treatment, consult a doctor immediately. This medication may affect liver function, so liver enzyme levels should be checked before and during treatment, and if liver dysfunction is severe, administration should be discontinued. Due to its blood pressure-lowering effects, hypotension or dizziness may occur, so caution is needed when driving or operating machinery. When used in combination with other antihypertensive medications or diuretics, potassium-sparing diuretics, etc., blood pressure, kidney function, and serum potassium levels should be monitored regularly. This medication may interact with certain drugs, so be sure to inform healthcare professionals about any other medications being taken. Pregnant or breastfeeding women should not take this medication, and breastfeeding should be discontinued if necessary. Safety in children has not been established, and use is not recommended. In case of overdose, appropriate treatment is required depending on the symptoms, and this medication is not removed by dialysis. When storing this medication, keep it out of the reach of children and store it in its original container.

Side effects and when to seek care immediately

Serious side effects

Hives, angioedema, chest tightness, difficulty breathing, cold sweat, paleness, severe allergic reactions, severe rash with high fever, blisters, skin peeling, pain in oral/eye mucosa, severe skin adverse reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory complications accompanied by cough and fever, respiratory issues, jaundice (yellowing of skin or eyes), extreme lethargy, liver dysfunction (jaundice), sudden and severe

Mild side effects

  • Headache
  • dizziness
  • rhinitis
  • fatigue
  • itching
  • dermatitis
  • joint stiffness
  • limb pain
  • glare
  • dyspepsia
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  • increased blood sugar
  • decreased serum sodium
  • hand fractures
  • hypoglycemia
  • nephrolithiasis
  • cough
  • tooth extraction
  • nausea
  • constipation
  • abdominal pain
  • diarrhea
  • loss of appetite
  • abdominal bloating
  • weakness
  • joint pain
  • muscle pain
  • increased CK
  • orthostatic dizziness
  • anxiety
  • depression
  • drowsiness
  • generalized itching
  • rash
  • hematuria
  • fever
  • relieved
  • chest discomfort
  • numbness

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a tightly closed container to prevent air or moisture from entering and kept at room temperature between 1°C and 30°C. This will help maintain the drug's effectiveness for a longer period.

Appearance and packaging

Appearance

Pink round film-coated tablets

Package unit

30 tablets (10 tablets/PTP X 3)

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.