Alpirevofloxacin Tablet 250 mg (Levofloxacin Hemihydrate)

Adult dose

In general, adult patients are to take 250–750 mg of levofloxacin orally once daily. For patients with normal kidney function (creatinine clearance greater than 80 mL/min), according to the indication, complicated skin and soft tissue infections receive 750 mg every 24 hours for 10–14 days, community-acquired pneumonia receives 500 mg every 24 hours for 7 days, acute bacterial exacerbation of chronic bronchitis for 7 days, acute sinusitis for 10–14 days, and chronic bacterial prostatitis for 28 days.

This drug is an antibiotic of the fluoroquinolone class used for the treatment of specific bacterial infections. However, it can cause serious side effects such as tendonitis or tendon rupture; therefore, it must be discontinued immediately if pain or inflammation symptoms occur. It should not be administered to patients with myasthenia gravis as symptoms may worsen, and it must be stopped immediately if serious adverse reactions occur. Additionally, this medication may pose a risk of seizures or central nervous system abnormalities, so caution is needed for patients with a history of brain disorders. Use in children, adolescents, pregnant women, and nursing mothers is not recommended as safety has not been established. Elderly patients may require dosage adjustment and monitoring due to potential higher drug concentrations from decreased kidney function. Caution is needed as interactions may occur when taken with certain antacids, non-steroidal anti-inflammatory drugs, and hypoglycemic agents. Patients should avoid exposure to sunlight or artificial ultraviolet light during treatment and discontinue the medication immediately if photosensitivity reactions occur. Immediate consultation with healthcare professionals is required if severe skin reactions or allergic symptoms occur, and caution should be exercised when driving or operating machinery if dizziness or drowsiness symptoms appear. In the case of overdose, central nervous system symptoms and cardiac issues may manifest, requiring immediate medical attention. Patients are advised to monitor for adverse symptoms and adhere strictly to the prescribed duration and dosage.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in oral/eye mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory distress accompanied by cough + fever, jaundice (yellowing of skin or eyes), extreme lethargy, sudden and severe headaches, lightning headaches, seizures, altered consciousness, visual disturbances, paralysis, urination issues

Mild side effects

• Nausea
• diarrhea
• vulvovaginitis
• insomnia
• abdominal pain
• bloating
• itching
• dizziness
• rash
• indigestion

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. Maintaining the storage temperature between 1 degree and 30 degrees Celsius at room temperature is essential. Proper storage will ensure the medication's effectiveness.

Appearance

Pale pink elongated film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle