Nuvigil Tablet 250 mg (Armodafinil)

Adult dose

Adults: Take 150mg once daily in the morning. The dose may be increased to a maximum of 250mg daily. The dose should be adjusted when coadministered with CYP3A4 substrate drugs such as triazolam and cyclosporine. Drugs eliminated through CYP2C9 and CYP2C19 metabolism, such as phenytoin, or mainly through CYP2C19 metabolism, such as diazepam, propranolol, and S-mephenytoin, have prolonged elimination when coadministered with this medicine; therefore, dose reduction and monitoring for toxicity are required. The dose should be reduced in patients with severe hepatic impairment.

This medication is used for patients with severe sleepiness, but in some cases, the state of wakefulness may not return to normal, so the level of sleepiness should be checked frequently. Activities such as driving or operating dangerous machinery should be avoided during the use of this drug. This medication can cause serious skin rashes and is not recommended for use in children. If symptoms such as rash, high fever, or vomiting occur, treatment should be stopped immediately and a doctor should be consulted. Severe allergic reactions such as angioedema or anaphylaxis can occur rarely, and if symptoms such as swelling of the face or neck or difficulty breathing develop, immediate medical attention should be sought. A condition called multi-organ hypersensitivity may occur, which can present with various symptoms such as fever, rash, and liver function abnormalities; if suspected, the medication should be stopped immediately. There is a risk of exacerbation of psychiatric symptoms, so patients with a history of depression, anxiety, or psychosis should be carefully monitored, and discontinuation should occur if symptoms arise. Since it may affect the heart and blood pressure, electrocardiogram tests and monitoring of blood pressure and heart rate are necessary before and during use. Patients with a history of heart disease should not use this medication. Women who are pregnant or breastfeeding, children under 18 years old, patients with moderate or severe hypertension, arrhythmia patients, and anyone allergic to this medication's ingredients should not take this drug. Patients with severely impaired liver or kidney function require dosage adjustments, and elderly patients should also be monitored closely based on their physical condition. Common side effects include headache, nausea, dizziness, insomnia, anxiety, diarrhea, dry mouth, depression, dyspepsia, fatigue, palpitations, upper abdominal pain, restlessness, decreased appetite, constipation, contact dermatitis, reduced appetite, depressive mood, attention disorders, shortness of breath, sweating, increased gamma-glutamyl transferase, increased heart rate, influenza-like illness, loose stools, migraine, irritability, pain, sensory abnormalities, polyuria, fever, and seasonal allergies. Drug interactions may occur, so be sure to inform your doctor, especially if you are taking contraceptives, antidepressants, anticonvulsants, anticoagulants, etc. In cases of overdose, symptoms such as insomnia, confusion, hallucinations, and heart issues may occur; immediate medical treatment should be sought, and there is currently no specific antidote for this medication. Long-term use may lead to dependence or abuse potential, so it should be taken according to a doctor's instructions, and if any abnormal symptoms occur, immediate consultation should be made.

• Drowsiness
• skin rash
• Stevens-Johnson syndrome
• toxic epidermal necrolysis
• angioedema
• anaphylactic-like reaction
• multiorgan hypersensitivity
• myocarditis
• hepatitis
• abnormal liver function tests

This medication may be sensitive to air or moisture, so keep it in a tightly sealed container. It is recommended to store at room temperature between 1 to 30 degrees Celsius. This will help maintain the drug's effectiveness over time.

Appearance

White or off-white oval tablet

Package unit

30 tablets/box [10 tablets/PTP X 3]