Nepain Injection (Nepofam Hydrochloride)

Adult administration

Administer 20 mg of nefopam hydrochloride by intramuscular or intravenous injection. If necessary, repeat every 6 hours, not exceeding 120 mg per day. Administer intravenous injections slowly over at least 15 minutes, and preferably have the patient lie still and rest for 15-20 minutes after administration. If administered in an infusion solution such as an electrolyte or glucose solution, administer 30 mg over 4 hours or 40 mg over 6-8 hours, in proportion to the administration time. Adjust the dose as appropriate according to age and symptoms.

This medication should be handled with care when using glass ampoules to avoid the risk of glass fragments. It should not be used in patients with epilepsy, those who have had a myocardial infarction, patients taking MAO inhibitors, those allergic to this drug or its components, children under 15, patients with a history of seizures, patients who have difficulty urinating due to urethral or prostate issues, and those with angle-closure glaucoma. Caution should be exercised when administering to elderly patients and in pregnant or breastfeeding women, as well as to patients taking anticholinergic drugs. This medication may cause side effects such as loss of appetite, nausea, drowsiness, vomiting, excessive sweating, dizziness, increased heart rate, thirst, difficulty in urination, injection site pain, headache, blurred vision, fatigue, nervousness, sleep disturbances, agitation, hallucinations, drug abuse, dependence, seizures, and allergic reactions. While it alleviates the symptoms of inflammation, it does not treat the underlying cause, so it should be used cautiously depending on the degree of acute inflammation, pain, and fever. Long-term use should be avoided, and the patient's condition should be closely monitored for abnormal reactions. When used for infectious inflammation, this should be accompanied by appropriate antimicrobial or antifungal agents, and the infection should be monitored closely. In elderly patients, it should be administered at the minimum effective dose and care taken with potential side effects. Liver and kidney function can affect drug metabolism and excretion, which should be considered. This medication can cause drowsiness or decreased activity; therefore, it is advisable not to operate vehicles or machinery during treatment. It is best to avoid using this drug with other non-steroidal anti-inflammatory drugs, and caution should be taken regarding hepatotoxicity when used with acetaminophen. There is a potential for increased adverse reactions when taken with specific drugs such as anticholinergic antispasmodics, anticholinergic antiparkinsonian drugs, tricyclic antidepressants, phenothiazine neuroleptics, and antihistamines. Use during pregnancy or breastfeeding is not recommended. Its safety and efficacy in children under 15 have not been established. It is not recommended for elderly patients due to anticholinergic side effects. In the case of overdose, immediate consultation with a doctor or pharmacist is essential; heart and respiratory status should be monitored, and appropriate treatment should be administered. Mixing this drug with others for injection should be avoided. For storage, keep it out of reach of children, avoid direct sunlight, and store it in a cool, dry place. Do not transfer the medication to another container to prevent misuse.

• Loss of appetite
• gastrointestinal disorders
• nausea
• drowsiness
• vomiting
• hyperhidrosis
• dizziness
• tachycardia
• palpitations
• thirst

This medication should be stored in a sealed container to prevent air and moisture from entering. It is recommended to maintain a storage temperature between 1 degrees and 30 degrees Celsius at room temperature.

Appearance

Colorless and transparent liquid in a colorless transparent glass ampoule

Package unit

50 ampoules/box [(2 milliliters/ampoule) × 50]