Whitetramaju (Tramadol Hydrochloride)

Adult administration

As Tramadol Hydrochloride, administer 50-100mg by intravenous injection or intramuscular injection once, repeating every 4-5 hours as needed. The maximum daily dose can be up to 400mg.

This medication can cause seizures if taken in excess of the recommended dosage, so the prescribed dosage must be strictly followed. Additionally, this medication may increase the risk of seizures, so it should only be used when absolutely necessary in patients with a history of epilepsy or seizure risk. Long-term use can lead to psychological and physical dependence, so patients at risk of drug abuse should be managed and administered strictly over a short term. Using this medication with alcohol or central nervous system depressants (such as benzodiazepines) can lead to severe sedation, respiratory depression, coma, and the risk of death, so this combination should be avoided or used in the minimum effective dose for the shortest time necessary with close monitoring of the patient. Individuals who metabolize this drug rapidly due to genetic factors may have higher levels of the active metabolite in the blood, increasing the risk of respiratory depression, thus requiring dose adjustments and symptom monitoring. This drug should not be used in children under 12 or adolescents under 18 who have undergone tonsillectomy or adenoidectomy. In adolescents aged 12 to 18 with risk factors for respiratory depression, administration is also discouraged. This medication should not be administered to patients with acute alcohol intoxication, central nervous system drug poisoning, severe respiratory depression, head injuries, patients taking or having taken MAO inhibitors within the past 14 days, patients with severe kidney and liver dysfunction, pregnant and breastfeeding women, and those with certain genetic disorders. Patients taking morphine or with a history of epilepsy or seizures, drinkers, and those who are sensitive to opioids should use this medication cautiously, as there is an increased risk of dependence in individuals with a history of drug abuse or mental illness. This medication may cause side effects such as drowsiness, dizziness, nausea, and vomiting, thus driving or operating dangerous machinery should be avoided after taking it. Long-term use may result in tolerance requiring increased dosages, and sudden discontinuation may provoke withdrawal symptoms; hence, the dosage should be gradually reduced. In the event of an overdose, severe respiratory depression and seizures may occur, requiring immediate emergency care, and naloxone may be used as an antidote if necessary. This medication may interact with various drugs, so anyone currently taking other medications must consult a doctor or pharmacist. It is safest for pregnant or breastfeeding women to avoid using this medication. In breastfeeding, caution is necessary as the drug may pass into breast milk and cause severe side effects in the infant. Elderly patients (those over 75 years) may have increased blood levels, so it is advisable to limit the dosage to 300mg per day.

Serious side effects

Seizures, hives, angioedema, anaphylaxis, severe allergic reactions, respiratory depression, difficulty breathing, asthma exacerbation, facial pallor, fainting, serious skin reactions (Stevens-Johnson syndrome), severe neurological symptoms (confusion, seizures, paralysis, visual disturbances), severe swelling, withdrawal symptoms, severe anaphylactic reactions, jaundice, elevated liver enzyme levels, severe adrenal insufficiency symptoms (severe abdominal pain, nausea, vomiting, hypotension, extreme

Mild side effects

• Drowsiness
• dizziness
• unsteadiness
• nausea
• vomiting
• abdominal bloating
• abdominal discomfort
• abdominal pain
• loss of appetite
• constipation

This medication should be stored in a sealed container to avoid contact with air and is best kept at room temperature between 1 and 30 degrees Celsius. Proper storage maintains the drug’s effectiveness and prevents degradation.

Appearance

Colorless and transparent ampoules containing a colorless liquid

Package unit

1ml/ampoule x 50 ampoules / BOX