Solenirol Tablets 4 mg (Methylprednisolone)

Adult use

The initial dosage may vary from 4 mg to 48 mg per day of methylprednisolone, depending on the symptoms of the specific disease. In general, a low dose is sufficient for less severe conditions, although a high initial dose may be required in certain patients. The initial dose should be maintained or adjusted until a satisfactory response is achieved. If a satisfactory clinical result is not obtained after a reasonable period, treatment should be discontinued and another appropriate therapy started. The dosage must be determined individually according to the various diseases being treated and the patient's response. After an adequate response is achieved, an appropriate maintenance dose should be determined by reducing the initial dose at suitable intervals until the lowest dose that maintains an adequate clinical response is reached. Continuous monitoring of the dosage is required. Circumstances that may require dosage adjustment include remission or worsening of the disease, individual patient response to the drug, and the effect on the patient of exposure to stressful situations that are not directly related to the symptoms of the disease being treated. In the latter case, it may be necessary to increase the dosage for a period sufficient to achieve a satisfactory response in the patient. After long-term treatment, gradual dose reduction is recommended when discontinuing the drug. Multiple sclerosis For treatment of acute exacerbations of multiple sclerosis, it is effective to administer prednisolone 200 mg daily for 1 week, followed by prednisolone 80 mg every other day for 1 month (methylprednisolone 4 mg is equivalent to prednisolone 5 mg). ADT (Alternate Day Therapy) Alternate-day therapy is a regimen in which twice the daily dose is administered on one morning every other day.

This medicine should not be administered to specific patients. For instance, it should not be used in patients who are allergic to this medicine or its components, or those with infections, especially systemic fungal infections or patients with herpes simplex, herpes zoster, or chickenpox, as it may worsen the infection. Furthermore, patients receiving live vaccines or those with genetic lactose intolerance ought to avoid this medication. There are patients who should be treated with caution. Patients with glaucoma, tuberculous diseases, cataracts, electrolyte imbalances, hypertension, thrombosis, recent intestinal anastomosis, acute myocardial infarction, etc., may experience worsening symptoms and should be used cautiously when necessary. Patients with diabetes, osteoporosis, renal failure, hypothyroidism, fatty liver, myasthenia gravis, elderly patients, epilepsy, and ulcerative colitis should also be monitored closely. This medicine can cause various side effects. Symptoms such as edema or hypertension due to fluid retention, muscle weakness, osteoporosis, gastrointestinal issues, skin changes, neurological and psychiatric symptoms, endocrine abnormalities, and eye diseases may arise, requiring immediate proper treatment if symptoms occur. Long-term use may lead to adrenal insufficiency; thus, abrupt cessation poses risks, and the dosage should be reduced gradually. The risk of infection is increased; therefore, careful attention to infection prevention is necessary, and exposure to chickenpox or measles should be avoided. This drug may interact with other medications; thus, if you are taking any other medicines, it is essential to inform healthcare professionals. Special caution is needed when used concurrently with heart medications, antibiotics, anticoagulants, hypoglycemic agents, diuretics, etc. During pregnancy, it should only be used if necessary, as it may affect the fetus, and during breastfeeding, it is advisable to discontinue nursing since the medication may be passed into breast milk. When administered to children, growth retardation may occur, so the minimum effective dosage should be used with careful observation of growth status. Elderly patients are at a higher risk of side effects due to infections, diabetes, osteoporosis, hypertension, etc., and should be treated with extra caution. Finally, contracting chickenpox or measles while on this medication could lead to fatal outcomes, so it is essential to check both the medical history and vaccination status, with particular attention to infection prevention.

Edema, sodium retention, potassium loss, fluid retention, hypokalemic alkalosis, congestive heart failure, hypertension, myasthenia, avascular necrosis of the femoral and humeral heads, steroid myopathy, muscle wasting, pathologic fracture of the iliac bone, osteoporosis, vertebral compression fracture, arthralgia, tendon rupture, increased ALT, increased AST, increased ALP, nausea, dry mouth, vomiting, abdominal pain, loss of appetite, increased appetite, peptic ulcer, abdominal bloating, pancreatitis, ulcerative esophagitis, diarrhea, delayed wound healing, facial erythema, thin and fragile skin, abnormal sweating, petechiae, purpura, skin reaction suppression, purpura, acne, hirsutism, alopecia, pigmentation, increased intracranial pressure, papilledema, seizures, dizziness, headache, insomnia, euphoria, depression, Cushing's syndrome, menstrual irregularities, childhood growth suppression, latent diabetes symptoms, secondary adrenal insufficiency, pituitary unresponsiveness, decreased glucose tolerance, increased demand for insulin or oral hypoglycemic agents, suppression of adrenocorticotropic hormone secretion, ocular hypertension, glaucoma, posterior subcapsular cataract, secondary eye infections due to fungi or viruses, retinal disorders, exophthalmos, nitrogen balance disturbance, immune system disorder, allergic reactions, shock, urticaria, anaphylactic reactions, hypersensitivity reactions

This medication must be stored in a tightly sealed container to protect it from air and moisture. It is important to maintain a storage temperature between 1 to 30 degrees Celsius.

Appearance

White oval tablets

Package unit

500 tablets/bottle, 30 tablets/bottle