Ezrovah Tablets 10/10 mg

Adult dose

This medication is administered once daily, regardless of meals. The dosage range is 10/5 mg to 10/20 mg daily. For the initial dose, 10/5 mg once daily is recommended. In patients who require more significant reductions in LDL cholesterol, dosages may be adjusted accordingly. After starting treatment or adjusting the dosage, lipid levels in the blood should be checked at intervals of at least 4 weeks and dosage adjusted accordingly.

This medication is a combination product containing both Rosuvastatin and Ezetimibe, primarily used for the treatment of hypercholesterolemia. Patients with muscle-related diseases or at risk of acute renal failure should use caution before taking this drug. If there are acute infections, hypotension, major surgery, trauma, or severe metabolic disorders, the use of this drug may need to be temporarily or completely halted. The following patients should not take this drug: those with allergies to its ingredients, those with active liver disease, those with unexplained persistent elevations in liver enzymes, those with muscle diseases, those currently taking cyclosporine, those with severe renal failure, pregnant women or women of childbearing potential, nursing mothers, and patients at high risk of myopathy or rhabdomyolysis. Patients particularly at risk for myopathy should have their serum creatine kinase (CPK) levels checked before administration, and if symptoms such as muscle pain, muscle cramps, or muscle weakness occur, they should consult a doctor immediately. If CPK levels exceed five times the upper limit of normal, this medication should be discontinued. Patients with liver function issues should also exercise caution. Those with elevated liver enzyme levels or signs of liver damage should undergo regular liver function tests, and if serious liver damage is suspected, this medication should be discontinued. This medication may interact with other drugs, so any currently taken medications should be reported to a physician. This is particularly important when used in conjunction with cyclosporine, fibrate-class medications, and anticoagulants such as warfarin. Pregnant or nursing women should not take this medication, and women of childbearing age should ensure appropriate contraception while taking it. Elderly patients or those with impaired renal function are also at high risk for myopathy and should exercise caution, while safety in pediatric patients has not been established and is therefore not recommended. In case of overdose, treatment and supportive care should be based on symptoms, and monitoring of liver function tests and blood CPK levels is crucial. This medication should be kept out of reach of children, and care should be taken not to change the container as it may negatively affect the quality.

Serious side effects

Urticaria, edema, chest tightness, difficulty breathing, cold sweat, pallor, high fever, severe rash, blistering, peeling of the skin, pain in the mucous membranes of the mouth and eyes, shortness of breath or difficulty breathing, asthma attacks, respiratory issues accompanied by coughing and fever, yellowing of the skin or eyes (jaundice), severe fatigue, sudden and severe headaches, thunderclap headaches, seizures, confusion, visual disturbances, paralysis, markedly reduced urine output

Mild side effects

• Nasal pharyngitis
• arthralgia
• headache
• ALT elevation
• AST elevation
• myalgia
• edema
• elevated serum bilirubin
• acneiform dermatitis
• pruritus

This medication is sensitive to air and moisture, so it must be stored in a sealed container. The storage temperature should be kept between 1 to 30 degrees Celsius at room temperature to maintain the medication's effectiveness for a longer time.

Appearance

White to almost white round film-coated tablets

Package unit

30 tablets (15 tablets/PTP × 2)