Unicupem 1g (Meropenem Hydrate)

Adult administration

As Meropenem Hydrate, administer 0.5 to 1 g daily (as potency) divided into 2 to 3 doses by intravenous infusion lasting over 30 minutes. For suspected infections in patients with pathogenic pneumonia, peritonitis, or neutropenia, administer 1 g (as potency) intravenously every 8 hours. For cystic fibrosis and meningitis, administer 2 g (as potency) intravenously every 8 hours. Assess the necessity of continued administration based on 3 days after commencement of dosing.

Child administration

In children over 3 months with bacterial meningitis, administer 40 mg per kg body weight by intravenous infusion lasting over 30 minutes every 8 hours, depending on the pathogen's susceptibility and the patient's condition and type of infection. In severe cases,

This medication should not be used in patients who have experienced severe allergic reactions or shock to this drug or its components in the past. Patients taking valproate should be cautious as this medication can lower the blood concentration of valproate, leading to seizures. Patients who have had severe allergic reactions to other carbapenem or beta-lactam antibiotics should avoid this drug. Patients with allergic tendencies such as asthma and easy development of allergy symptoms like rash should use this medication with caution. Patients with impaired renal function may have increased concentrations of the drug, leading to central nervous system side effects, so dosage adjustment or increased intervals may be necessary. Patients with epilepsy or central nervous system disorders may experience seizures or consciousness disturbances when using this drug, thus caution is needed. Patients with severely impaired liver function, the elderly, infants, and those with poor nutritional status or difficulty in oral intake also require special caution. This drug can rarely cause shock, severe allergic reactions, blood abnormalities, liver or kidney dysfunction, gastrointestinal issues, central nervous system disorders, respiratory and skin reactions, thus patients must be monitored closely during administration. If rash or liver function abnormalities occur, discontinue use immediately and seek appropriate treatment. To reduce the occurrence of resistant bacteria, it should only be used for the minimum period necessary after susceptibility testing, and if susceptibility is not confirmed, discontinuation or switching to another drug is advisable. Prior to administration, always check the patient's history of allergy to beta-lactam antibiotics. Caution is required when driving or operating machinery as symptoms like headache, dizziness, and mental confusion may occur. If muscle pain, muscle weakness, or dark urine are observed, they may indicate muscle damage, and the healthcare provider should be informed immediately. This medication may interact with specific drugs, so patients should inform their healthcare provider if they are taking other medications. Pregnant women or those who may become pregnant should carefully consider the benefits and risks of this medication before use, and breastfeeding mothers are advised to avoid use. It is advisable not to use this drug in infants under 3 months as safety and efficacy have not been established. In the elderly, body functions decline and side effects may easily occur, hence dosage adjustment and monitoring of the condition are necessary. This medication should only be administered intravenously, and it should be used quickly after dissolution and stored for the prescribed time.

Serious side effects

Shock, severe allergic reactions, anaphylaxis, serious skin reactions, toxic epidermal necrolysis, Stevens-Johnson syndrome, DRESS syndrome, erythema multiforme, acute generalized exanthematous pustulosis, liver failure, jaundice, fulminant hepatitis, acute renal failure, severe kidney impairment, severe diarrhea (pseudomembranous colitis), seizures, consciousness disturbances, central nervous system symptoms, asthma, respiratory distress, pleural effusion, pulmonary edema, seizure pneumonia, pulmonary embolism, heart failure.

Mild side effects

• Hives
• rash
• warmth
• erythema
• itching
• fever
• flushing
• generalized erythema
• angioedema
• oral discomfort

This drug should be stored in a tightly sealed container to prevent air entry and kept at room temperature between 1°C and 30°C. This will help maintain the drug's efficacy and prevent degradation.

Appearance

[For Domestic Use] A powder for injection, crystalline and white to pale yellow, contained in a colorless and transparent vial. [For Export] A colorless and transparent vial filled with a crystalline powder, white to pale yellow.

Package unit

10 vials/box