Duvimet Extended-Release Tablet 0.25/500 mg

Adult dose

This medication is generally administered once daily with the evening meal, incrementally adjusting the dosage to reduce gastrointestinal side effects associated with metformin. For this medication at 0.5/1000 mg extended-release, take 1 tablet once a day. Patients taking 0.25/500 mg, 0.25/750 mg, or 0.25/1000 mg extended-release tablets should take 2 tablets simultaneously once daily. The maximum daily dosage is not to exceed the provided recommendations.

This medication should be used cautiously in patients with conditions that stress the heart. In particular, it is advisable not to use this medication in patients with heart failure or those with a history of heart failure. During treatment, symptoms of heart failure such as weight changes, shortness of breath, and edema should be carefully monitored. If such symptoms occur, inform the healthcare provider immediately to evaluate the condition and receive appropriate action. This medication should not be used in patients with impaired kidney function, and regular checks should be conducted to ensure kidney function is normal. It is also safer for patients with liver dysfunction to avoid this medication. This medication can rarely cause severe metabolic acidosis, known as lactic acidosis, therefore if symptoms such as weakness, muscle pain, difficulty breathing, or abdominal pain occur, visit a hospital immediately. Excessive alcohol consumption increases the risk of lactic acidosis, so alcohol should be avoided while taking this medication. When used with other medications that lower blood sugar, there is a risk of hypoglycemia, so it is essential to regularly monitor blood sugar levels and remain vigilant. Women who are pregnant or might become pregnant, as well as nursing mothers, should not use this medication. Caution is needed as the safety and efficacy of this medication have not been sufficiently verified in children or the elderly. In case of overdose, inform the healthcare provider immediately and receive necessary treatment. This medication may interact with other drugs, so it is essential to inform the physician or pharmacist about any other medications being taken. If during treatment there are signs of weight gain, edema, fatigue, or liver dysfunction, consult the healthcare provider immediately. Due to the characteristics of thiazolidinedione class drugs, there is an increased risk of fractures, thus care should be taken regarding bone health. While taking this medication, it is crucial to strictly adhere to the prescribed dosage and schedule, and not to arbitrarily increase or decrease the dosage. Regular blood tests and kidney and liver function checks during treatment are important.

Serious side effects

Edema, excessive and rapid weight changes, shortness of breath, dyspnea, difficulty breathing, heart failure, lactic acidosis, liver dysfunction (increased ALT, increased AST, jaundice), acute kidney failure, acute myocardial infarction, sepsis, headache, seizures, confusion, visual disturbances, paralysis, hypoglycemia, severe edema accompanied by increased blood pressure, kidney function decline, increased serum creatinine, acute respiratory distress syndrome, worsening asthma, pulmonary edema, pneumonia, brainstem infarction

Mild side effects

• Headache
• chest pain
• dental caries
• dental diseases
• constipation
• diarrhea
• heartburn
• cold symptoms
• upper respiratory tract infection
• cough

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. The storage temperature should be maintained between 1 to 30 degrees Celsius at room temperature.

Appearance

Blue elongated extended-release film-coated tablet

Package unit

Bottle packaging - 30 tablets/bottle