Papillon Sustained Release Tablet (Bupropion Hydrochloride)

Adult dose

Swallow this medication whole. Do not crush, split, or chew it. Doing so may increase the risk of adverse reactions, including seizures. Short-term adjunctive treatment of nicotine dependence during smoking cessation Administer 150mg once daily for 6 days as the initial dose, then increase to 150mg twice daily. Doses should be taken at least 8 hours apart. The maximum dose per administration should not exceed 150mg, and the total daily dose should not exceed 300mg. Patients should receive this medication for at least 7 weeks. No dosage adjustment is necessary when this medication is coadministered with a nicotine patch to treat nicotine dependence. Depression The usual target dose of this medication in adults is 150mg twice daily (300mg/day). Administer 1 tablet once in the morning (150mg/day, 150mg once daily) for at least 4 days. If the patient tolerates it adequately, increase to 1 tablet twice daily (300mg/day, 150mg twice daily), with at least 8 hours between doses. For patients whose symptoms have not improved after several weeks at 300mg/day, an increase to a maximum of 400mg/day (200mg twice daily) may be considered. Long-term efficacy was demonstrated when the same dose of this medication (150mg twice daily) was administered as maintenance therapy for 44 weeks. Use this medication with extreme caution in patients with severe cirrhosis, and do not exceed 100mg per day or 150mg every 2 days in these patients. Use this medication with caution in patients with hepatic impairment (including mild to moderate cirrhosis); in patients with mild to moderate cirrhosis, consider reducing the frequency and/or dose. Use this medication with caution in patients with renal impairment, and consider reducing the frequency and/or dose.

Child dose

The safety and efficacy of this medication in patients under 18 years of age have not been established.

This medicine may increase the risk of suicidal thoughts or actions in young patients with major depressive disorder or psychiatric disorders, thus caution should be exercised when administering it to patients, particularly those aged 18 to 24. When used for smoking cessation, depressive or suicidal symptoms may occur; therefore, patient behavioral changes should be closely monitored during treatment, and if abnormal symptoms appear, a doctor should be consulted immediately. This medication carries a risk of seizures; therefore, it should not be administered to patients with a history of seizures or taking other medications that increase seizure risk. In patients with impaired liver or kidney function, the metabolism and excretion of this medication may be affected, so dosage adjustments and careful monitoring are necessary. For patients with cardiovascular diseases, caution is warranted as the safety of this medication has not been fully established. During treatment with this medication, allergic reactions or severe skin hypersensitivity reactions may occur; thus, if symptoms such as rash, itching, or difficulty breathing arise, administration should be stopped and medical attention sought immediately. Initially, symptoms such as agitation, insomnia, and anxiety may occur; if these symptoms are severe, consultation with a physician is advised. This medication may affect judgment or concentration, so caution should be exercised when driving or operating machinery. Women who are pregnant or planning to become pregnant should consult a physician before taking this medication, and those who are breastfeeding should consider stopping breastfeeding or discontinuing the medication. This medication is not approved for use in children and adolescents under 18 years of age, and elderly patients may require dosage adjustments considering potential kidney function decline. In the event of overdose, serious side effects such as seizures, loss of consciousness, and cardiac arrhythmias may occur, so prescribed doses must be strictly adhered to, and if an overdose is suspected, medical facilities should be visited immediately. This medication should not be combined with other antidepressants or drugs containing bupropion, as the risk of seizures may increase. Additionally, this medication inhibits the CYP2D6 enzyme; therefore, when used with other medications metabolized by this enzyme, dosage adjustment and caution are necessary. When taking this medication, it should be swallowed whole without chewing or splitting; changing the release rate of the medication may increase the risk of side effects. Alcohol intake may worsen the side effects of this medication; therefore, alcohol consumption should be avoided during the treatment period. Finally, this medication should be stored out of reach of children and not transferred to other containers for safety.

Suicidal impulses, suicidal ideation, suicide attempts, depression, restlessness, hostility, aggression, anger, worsening of nicotine withdrawal symptoms, nausea, dry mouth, constipation, diarrhea, loss of appetite, oral ulcers, thirst, muscle pain, joint pain, insomnia, abnormal dreams, anxiety, concentration difficulties, dizziness, nervousness, tremors, discomfort, rhinitis, increased cough, pharyngitis, sinusitis, difficulty breathing, nosebleeds, reactions at patch application sites, rash, itching, hives, altered taste, tinnitus, frequent urination, headache, infection, abdominal pain, weakness, chest pain, pain, fever, flushing, tachycardia, elevated blood pressure, orthostatic hypotension, vasodilation, syncope, hypotension, abnormal dreams, memory impairment, paresthesia, headache, restlessness, agitation, confusion, delusions, paranoid thinking, hallucinations, irritability, depersonalization, Parkinsonism, dystonia, ataxia, spasms, inability to cooperate, blood sugar disorder, weight loss, elevated liver enzyme levels, jaundice, hepatitis, sweating, angioedema, anaphylactic shock, joint pain, fever, erythema multiforme, Stevens-Johnson syndrome, visual disturbances, vaginal bleeding, urgent urination, urinary tract infection, dysphagia, vomiting, dysphagia, migraines, trauma-related injuries, acne, increased appetite, back pain, bronchitis, dysmenorrhea, dyspepsia, pneumatosis intestinalis, influenza symptoms, hypertension, neck pain, vasodilation, stroke, complete heart block, ectopic beats, myocardial infarction, thrombophlebitis, pulmonary edema, bruxism, gastroesophageal reflux, gingivitis, glossitis, increased salivation, tongue swelling, colitis, esophagitis, gastrointestinal bleeding, gingival bleeding, liver damage, pancreatitis, gastric ulcer, leg cramps, muscle rigidity, muscular weakness, cooperation difficulties, decreased libido, discomfort, emotional instability, hyperactivity, excessive muscle tension, sensory decrease, amnesia, ataxia, derealization, hypomania, abnormal EEG patterns, motor disability, aphasia, coma, suicide, delirium, speech disorders, movement disorders, sense of well-being, extrapyramidal syndrome, reduced motor activity, increased libido, manic response, neuralgia, neuropathy, paranoid thinking, suicide attempts, tardive dyskinesia, bronchospasm, pneumonia, erectile dysfunction, polyuria, prostate disorders, ejaculation abnormalities, cystitis, dyspareunia, dysuria, gynecomastia, menopause, pain during erection, salpingitis, urinary incontinence, urinary retention, vaginitis, hyperglycemia, hypoglycemia, inappropriate antidiuretic hormone symptoms, edema, peripheral edema, diabetes, petechiae, anemia, leukocytosis, leukopenia, lymphadenopathy, pancytopenia, thrombocytopenia, maculopapular rash, alopecia, angioedema, dermatitis exfoliativa, hypertrichosis, pupillary control disturbances, dry eyes, hearing loss, diplopia, increased intraocular pressure, pupillary dilation, drowsiness, loss of consciousness, conduction disturbances, arrhythmia, hallucinations, paradoxical tachycardia, conduction disturbances, fever, muscle rigidity, rhabdomyolysis, hypotension, sensory paralysis, coma, respiratory failure, schizophrenia-like response, Parkinsonism, depersonalization, pancreatitis, sequelae of intracranial injury, fracture, prostate disorders, psychosis, confusion, diarrhea, chest pain, difficulty breathing, pharyngitis, visual disturbances, weight loss, anxiety, weakness, dyspepsia, abnormal dreams, palpitations, nervousness, drowsiness, delirium, muscle rigidity, depression, hallucinations, confusion, vomiting, restlessness, bipolar disorder, suicidal tendencies, suicidal behaviors, suicide attempts, psychosis, hallucinations, paranoia, delusions, homicidal thoughts, panic, suicidal ideation, suicide attempts, suicide, itching, hives, angioedema, anaphylaxis-like reactions, skin rash, chest pain, edema, shortness of breath, hypertension, increased blood pressure, postural hypotension, stroke, syncope, complete heart block, ectopic beats, myocardial infarction, thrombophlebitis, pulmonary edema, bruxism, gastritis, jaundice, oral ulcers, hepatitis, erythema multiforme, Stevens-Johnson syndrome, menorrhagia, alcoholism, skin diseases, sleep apnea, increased sputum, hemoptysis, reduced urine flow, intracranial hemorrhage, schizophrenia-like response, communication disorders, sequelae of intracranial injury, seizures, coma, movement disorders, paralysis

This medication should be stored in a tightly sealed container that blocks light and prevents air exposure. Additionally, it is important to store it in a cool place below 25 degrees Celsius to maintain its effectiveness.

Appearance

Biconvex white round sustained release film-coated tablet

Package unit

28 tablets (14 tablets/PTP × 2)