Diapolmin Tablet 1000 Milligrams (Metformin Hydrochloride)

Adult dosage

The dosing regimen should be determined based on individual drug efficacy and tolerability, and should not exceed the recommended maximum daily dose. The medication should be started at a low dose to minimize gastrointestinal side effects and to ascertain the minimum effective dose needed for proper blood sugar control, typically given 500 mg 2 to 3 times a day with meals. Dosage increments should be made gradually, by 500 mg weekly to a maximum of 2000 mg.

Children's dosage

Can be used in children aged 10 years and older or adolescents during their growth period. The typical starting dose is 500 mg once daily, administered with meals or shortly after eating. After one week, blood sugar levels should be monitored to adjust the dosage.

This medication may cause severe lactic acidosis or hypoglycemia, so caution is necessary. It should not be administered to patients with moderate to severe renal impairment or those in states that may affect renal function, such as acute infection or heart failure. Patients undergoing tests using radiographic iodine contrast agents must temporarily discontinue this medication before and after the test, resuming only after renal function has returned to normal. It is contraindicated in patients who have had allergic reactions to this medication or biguanides, those with type 1 diabetes, and those with severe metabolic acidosis. Treatment should be temporarily halted in cases of severe infection, serious trauma, or surgery, and can be resumed once the patient's condition stabilizes. Patients with impaired liver function or excessive alcohol intake are also not suitable candidates for this medication. Caution should be exercised in patients with irregular blood sugar control, low food intake, or those undergoing vigorous exercise or interacting with other medications. Lactic acidosis is rare but a very serious side effect; if symptoms such as malaise, muscle pain, difficulty breathing, or abdominal pain occur, immediate medical attention should be sought. Gastrointestinal disturbances may occur while taking this medication, which are common initially but typically resolve over time. Rarely, side effects such as skin rashes, anemia, liver function abnormalities, and hypoglycemia (rarely severe delayed hypoglycemia) may occur. Regular renal function examinations should be conducted to reduce the risk of accumulation and side effects, especially in elderly patients or those with weakened renal function. Alcohol can influence lactate metabolism, increasing the risk of lactic acidosis, so patients should avoid alcohol during treatment. During pregnancy, this medication crosses the placenta, necessitating close monitoring of fetal growth, and is not used in cases of certain pregnancy complications. While this medication is excreted in breast milk, there have been no reported adverse reactions in infants, but the decision to continue treatment and breastfeeding should be made carefully. It can be used in children and adolescents, but growth and development should be monitored closely. In cases of overdose, there is a risk of lactic acidosis, and treatment should be sought immediately at a medical facility, with hemodialysis available for drug removal. Co-administration with other medications may alter blood sugar control effects, so careful monitoring of blood glucose and patient condition is required. This medication does not cause weight gain and may assist in weight maintenance or loss.

Serious side effects

Lactic acidosis, severe allergic reactions (hives, severe swelling), severe skin adverse reactions (severe rash with fever, blisters, skin peeling, pain in mouth/eye mucosa), respiratory problems (difficulty breathing or worsening asthma, coughing with fever indicative of respiratory issues), symptoms of liver problems (jaundice, generalized weakness), serious neurological symptoms (sudden and severe headache, thunderclap headache, seizures)

Mild side effects

Diarrhea, nausea, vomiting, abdominal bloating, loss of appetite, indigestion, constipation, abdominal pain, unpleasant or metallic taste, rash, anemia, leukopenia, thrombocytopenia, vitamin B12 deficiency, liver function abnormalities, hypoglycemia (rarely severe delayed hypoglycemia)

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is important to maintain a storage temperature between 1 and 30 degrees Celsius. This ensures that the effectiveness of the medication is well preserved and prevents degradation.

Appearance

White, rectangular film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle