Arizet 10 mg Tablets (Donepezil Hydrochloride Hydrate)

Adult dose

As Donepezil Hydrochloride, administer 5 mg once daily before bedtime. If unusual dreams, nightmares, or sleep disturbances occur, morning dosing may be considered. The concentration of Donepezil reaches a steady state after 15 days of administration, thus the 5 mg dose should be administered for 4 to 6 weeks. After evaluating the clinical response during this period, the dose may be increased to 10 mg. When increasing to 10 mg daily, watch for gastrointestinal adverse reactions.

Child dose

There is no experience with pediatric use.

This medication is used for the treatment of symptoms of Alzheimer's-type dementia, with Donepezil Hydrochloride Hydrate as the active ingredient. This medication should not be administered to certain patients. For example, individuals with allergies to this drug or its components, pregnant or potentially pregnant women, nursing mothers, and patients with lactose intolerance or certain genetic lactose metabolism disorders should not use this medication. Patients with heart diseases or a history of peptic ulcer disease, asthma, or obstructive pulmonary disease, and those with extrapyramidal disorders such as Parkinson's disease should use this medication with caution as it can slow heart rate or exacerbate gastrointestinal symptoms. Various adverse reactions may occur while taking this medication, necessitating careful attention. Severe cases could lead to fainting, heart issues, gastrointestinal bleeding, liver dysfunction, cerebrovascular problems, muscular abnormalities, etc. Additionally, symptoms such as nausea, vomiting, diarrhea, dizziness, insomnia, hallucinations, anxiety, and depression may also occur. This medication is approved for use only in patients with Alzheimer's-type dementia and is not used for other forms of dementia or memory disorders. The therapeutic effect should be evaluated regularly, and if there is no efficacy, it is advisable to discontinue treatment. Patients with cardiovascular diseases may require ECG monitoring while taking this medication due to the risk of arrhythmias or fainting. This medication may affect the ability to drive or operate machinery, so caution is advised during initial dosing or when changing the dose. This medication can interact with various drugs. In particular, the drug's efficacy can change when used in conjunction with certain antifungals, antibiotics, antidepressants, and antiarrhythmics, so it is essential to consult a doctor or pharmacist. It is advisable for pregnant or nursing women not to use this medication, and if absolutely necessary, to follow the guidance of a specialist. Safety regarding pediatric use has not been established; therefore, it should not be administered to children. In case of overdose, severe adverse reactions such as nausea, vomiting, bradycardia, and respiratory depression may occur; if this happens, seek appropriate medical treatment immediately. This medication should be kept out of reach of children and should not be transferred to other containers.

Serious side effects

• Hives
• severe swelling (edema)
• difficulty breathing
• jaundice
• hepatitis
• liver dysfunction
• severe swelling or urinary abnormalities
• fainting
• bradycardia
• heart block

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headache
• fatigue
• dizziness
• insomnia
• tremors
• drowsiness

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. It is best stored at room temperature between 1 to 30 degrees Celsius.

Appearance

Yellow round film-coated tablet

Package unit

Bottle packaging - 30 tablets/bottle