Neopezil Tablet 10 mg (Donepezil Hydrochloride Hydrate)

Adult dose

As Donepezil Hydrochloride, administer 5 mg once daily at bedtime. After 15 days, the concentration reaches a steady state, and clinical response is assessed while maintaining the 5 mg dosage for 4–6 weeks. Afterward, the dose can be increased to 10 mg, but caution should be exercised regarding gastrointestinal adverse reactions when increasing to 10 mg. Underweight women over 85 years of age should not exceed 5 mg daily and require careful monitoring.

Child dose

There is no experience with pediatric use.

This medication is used to relieve symptoms of Alzheimer's disease, containing Donepezil Hydrochloride as the main ingredient. This medication should not be used by patients who are allergic to Donepezil Hydrochloride or other components of this medication, women who are pregnant or may become pregnant, and women who are breastfeeding. Additionally, as it contains lactose, it should not be administered to patients with genetic metabolic disorders such as galactose intolerance, lactase deficiency, and glucose-galactose malabsorption. Patients with heart disease or conduction disorders should use this medication cautiously, as it may slow down the heart rate or induce arrhythmias. Patients taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcers should be careful when administering this medication, as it can increase gastric acid secretion and gastrointestinal motility, potentially worsening ulcer symptoms. Patients with asthma or obstructive pulmonary disease should also be cautious, as it may increase bronchoconstriction and mucus secretion, exacerbating symptoms. Patients with extrapyramidal disorders such as Parkinson's disease may need to exercise caution, as this medication may worsen symptoms. This medication contains Yellow No. 5 dye, so those allergic to this component should use it carefully. Serious side effects such as fainting, bradycardia, heart block, gastrointestinal bleeding, liver dysfunction, seizures, extrapyramidal symptoms, rhabdomyolysis, and respiratory distress may occur during the use of this medication, so consult a doctor immediately if any abnormal symptoms arise. Various side effects have been reported, such as diarrhea, nausea, vomiting, dizziness, insomnia, headache, fatigue, muscle pain, rash, itching, urinary incontinence, increased urination, blood pressure fluctuations (hypertension, hypotension), edema, constipation, abdominal pain, dehydration, hives, sweating, hematological abnormalities (anemia, leukopenia, etc.), hallucinations, aggressive behavior, tremors, gait disturbances, involuntary movements, decreased concentration, mental dullness, and lethargy. It is important to inform medical personnel if such symptoms occur. This medication can affect heart conduction; thus, patients with heart disease or a history of QT interval prolongation should have their heart condition regularly checked through ECG tests. Caution is advised when driving or operating machinery, as dizziness or drowsiness may occur. This medication may interact with other drugs, so it is essential to inform the physician or pharmacist if taking any medications that affect CYP3A4 or CYP2D6, anticholinergic drugs, cardiac medications, NSAIDs, etc. Pregnant or breastfeeding women are generally advised not to use this medication; if necessary, a careful decision should be made after consulting a healthcare professional. Safety in pediatric use has not been established, and its use in children is not recommended. In case of overdose, symptoms such as nausea, vomiting, bradycardia, hypotension, and respiratory depression may occur, necessitating immediate treatment, and antidotes such as atropine might be used. This medication should be stored out of reach of children and not transferred to other containers for safety.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, oral/eye mucosal pain, shortness of breath or difficulty breathing, asthma attacks, respiratory difficulties accompanied by cough and fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden severe headache, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis, urination

Mild side effects

Nausea, vomiting, diarrhea, decreased appetite, headache, fatigue, drowsiness, dizziness, insomnia, rash, itching, muscle pain, urinary incontinence, increased urination, blood pressure fluctuations (hypertension, hypotension), edema, constipation, abdominal pain, dehydration, hives, sweating, blood abnormalities (anemia, leukopenia, etc.), hallucinations, aggressive behavior, tremors, gait disturbances, involuntary movements, decreased concentration, mental dullness, lethargy

This medication should be stored in a tightly closed container to prevent air ingress and kept at room temperature between 1 to 30 degrees Celsius. Proper storage ensures the maintenance of the drug's efficacy and prevents degradation.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle