Dubimet Extended-Release Tablets 0.25/1000 mg

Adult dose

The usual dosage of this medication is taken once daily with the evening meal, and the dosage is adjusted gradually to reduce gastrointestinal side effects related to metformin. The 0.5/1000 mg extended-release tablet is taken once daily, with one tablet per dose. The 0.25/500 mg, 0.25/750 mg, and 0.25/1000 mg extended-release tablets are taken once daily, with two tablets per dose at the same time. The initial dosage is 0.5 mg of rosiglitazone once daily.

This medication should be used cautiously under medical supervision in patients with weak heart function as it may exacerbate heart failure. After administration, careful observation is required for symptoms of heart failure, such as changes in weight, shortness of breath, and edema. This medication should not be used in patients with severe heart failure or significantly impaired kidney function. It is also advisable for patients with liver function impairment to avoid this medication. Rarely, this medication can cause severe lactic acidosis, so immediate consultation with a doctor is necessary if symptoms occur. Special caution is advised for elderly patients with impaired kidney function or those in poor condition due to dehydration or infection. When used in combination with other diabetes medications, hypoglycemia may occur, thus monitoring blood sugar levels is crucial. Women who are pregnant or breastfeeding should not use this medication. Regular blood tests and kidney and liver function tests should be conducted during medication use, and any unusual symptoms should be reported to healthcare providers promptly. Alcohol consumption should be avoided as it may increase the risk of lactic acidosis. Before and after surgery or radiological examinations, administration should be paused for a certain period, and treatment can be resumed only after confirming normal kidney function. Weight gain or edema may occur, so it is important to monitor these symptoms alongside dietary adjustments. This medication has not been proven safe and effective for children, so it is not used for them. In cases of overdose, appropriate emergency treatment is necessary, as some components may not be removed by dialysis.

Serious side effects

Edema, symptoms and signs of heart failure (including excessive and rapid weight change, shortness of breath, edema), lactic acidosis, hypoglycemia, severe allergic reactions (hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor), severe skin reactions (severe rash with fever, blistering, skin peeling, oral/ocular mucosa pain), respiratory issues (difficulty breathing or shortness of breath, asthma attacks, respiratory issues accompanied by cough and fever)

Mild side effects

• Headache
• chest pain
• dental caries
• dental disease
• constipation
• diarrhea
• heartburn
• cold
• upper respiratory infection
• cough

This medication should be stored in a tightly closed container to prevent exposure to air or moisture. It should also be kept away from excessively hot or cold places, ideally at temperatures between 1°C to 30°C at room temperature.

Appearance

Blue, rectangular extended-release film-coated tablets

Package unit

Bottle packaging - 30 tablets/bottle