Clarithromycin 250 mg (Clarithromycin)

Adult dosage

Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7～14 days. In patients with renal failure and creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or 250mg (potency) twice daily for severe infections. Do not administer to these patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) of this drug twice daily. In this case, it should be administered in combination with other antimycobacterial agents, such as ethambutol, clofazimine, and rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this drug 3 times daily for 14 days in combination with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

Pediatric patients aged 12 years or older: Same as for adults. For pediatric patients under 12 years of age, use clarithromycin dry syrup.

This medication should not be used in patients with allergies to specific components. Patients with hypersensitivity to macrolide antibiotics should also avoid use. Individuals with heart rhythm problems or severe liver and kidney dysfunction should use this medication cautiously. Women who are pregnant or breastfeeding should not take this medication. Serious side effects may occur when this drug is taken with certain other medications, so it is essential to consult a doctor before concomitant administration. While using this medication, patients should be closely monitored for allergy reactions, severe gastrointestinal disorders, liver dysfunction, and kidney dysfunction symptoms. Caution is also needed when driving or operating machinery as dizziness or mental symptoms may occur. Prolonged or high-dose use may lead to auditory disturbances or tinnitus, and if any unusual symptoms arise, the healthcare provider should be notified immediately. In particular, elderly patients or those with weakened liver or kidney function may require dosage adjustments, so they should follow their doctor's instructions. To prevent antibiotic resistance, this medication should only be taken for the necessary duration, and if there are any abnormal symptoms like diarrhea during treatment, immediate consultation with a healthcare provider is required.

Shock, anaphylactic symptoms, dyspnea, convulsions, flushing, rash, pruritus, urticaria, skin flushing, angioedema, joint swelling, drug-induced rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, tooth discoloration, pancreatitis, elevated amylase, dysgeusia, appetite loss, constipation, discoloration of stools, pseudomembranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltrate, interstitial pneumonia, chronic bronchitis, exacerbation of acute maxillary sinusitis, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, feelings of numbness, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, elevated liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, taste distortion, hearing loss, paresthesia, arthralgia, myalgia, olfactory disturbance, tinnitus, hearing impairment, hypoglycemia, purpuric rash, acute generalized exanthematous pustulosis (AGEP), muscle cramps, musculoskeletal stiffness, myopathy, elevated blood urea, phlebitis at the injection site, pain at the injection site, inflammation at the injection site, fever, asthenia, chest pain, chills, fatigue, abnormal albumin/globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, discoloration of urine

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. It is advisable to maintain a storage temperature between 1 degree and 30 degrees Celsius. This way, the efficacy of the medication can be preserved for a longer duration.

Appearance

Oval film-coated tablets with a yellow color and vanilla flavor.

Package unit

30 tablets/bottle, 200 tablets/bottle