Fene Tablet 5 mg (Donepezil Hydrochloride Monohydrate)

Adult dose

○ Adults: Administer donepezil hydrochloride 5 mg once daily at bedtime. If sleep disturbances such as abnormal dreams, nightmares, or insomnia occur, taking this medicine in the morning may be considered. Since donepezil concentrations reach steady state 15 days after administration and the incidence of adverse reactions may be affected by the rate of dose escalation, administer the 5 mg dose for 4~6 weeks. After evaluating the clinical response during this period, the dose may be increased to 10 mg. When increasing the dose to 10 mg daily, administer with caution for gastrointestinal adverse reactions. When treatment with this medicine is discontinued, its effect gradually diminishes; no rebound effect occurs with abrupt discontinuation. ○ Female patients aged 85 years or older with low body weight: Careful monitoring is necessary because adverse reactions occur more frequently. Elderly women with low body weight should not exceed 5 mg daily.

Child dose

○ Children: There is no experience with use in children.

This medication contains the ingredient donepezil hydrochloride and is used for treating Alzheimer's type dementia symptoms. First, this medication should not be administered to certain patients. For example, individuals who are allergic to this medication or its components, women who are pregnant or may become pregnant, women who are breastfeeding, and individuals with lactose intolerance or specific genetic metabolic disorders should avoid taking this medication. Furthermore, patients with heart disease or heart conduction disorders, those with a history of peptic ulcers or who are taking non-steroidal anti-inflammatory drugs, patients with asthma or obstructive lung disease history, patients with extrapyramidal disorders such as Parkinson's disease, and those allergic to certain dyes contained in this medication should use it with caution. Various side effects may occur when taking this medication. Cardiac-related issues may include bradycardia, heart block, myocardial infarction, while gastrointestinal problems may include exacerbation of peptic ulcers, gastrointestinal bleeding, nausea, vomiting, and diarrhea. Neurological cases have reported hallucinations, anxiety, insomnia, seizures, and musculoskeletal issues such as muscle pain or rhabdomyolysis should also be monitored. This medication may affect the cardiovascular system, so patients with a history of heart disease may require regular electrocardiograms. Additionally, it may promote gastric acid secretion, increasing the risk of exacerbating peptic ulcers, thus caution regarding gastric health is advised. It may also impact driving or machinery operation abilities, so care is needed in the initial intake or upon dosage changes. Women who are pregnant or breastfeeding are advised against using this medication unless necessary; in such cases, consultation with a healthcare professional is recommended. This medication may interact with various drugs, so consulting a doctor or pharmacist is crucial if other medications are being taken, especially when taken with medications affecting the heart, antibiotics, antidepressants, or antipsychotics. In cases of overdose, severe symptoms such as nausea, vomiting, bradycardia, or respiratory depression may occur, and immediate medical attention is needed. Lastly, this medication should be kept out of reach of children, and it is advisable to avoid transferring it to another container.

• Syncope
• bradycardia
• heart block
• prolonged QT interval
• myocardial infarction
• heart failure
• peptic ulcer
• perforated duodenal perforation
• gastrointestinal bleeding
• hepatitis

This medication should be stored in a tightly closed container to prevent air or moisture ingress and should be kept at a temperature between 1°C and 30°C (33.8°F to 86°F). Storing it this way helps maintain the medication’s efficacy and prevent deterioration.

Appearance

Yellow round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle