Phenido Tablet 10 mg (Donepezil Hydrochloride Monohydrate)

Adult dose

○ Adults: Administer donepezil hydrochloride 5 mg once daily at bedtime. If sleep disturbances such as abnormal dreams, nightmares, or insomnia occur, taking this medicine in the morning may be considered. Since donepezil concentrations reach steady state 15 days after administration and the incidence of adverse reactions may be affected by the rate of dose escalation, administer the 5 mg dose for 4~6 weeks. After evaluating the clinical response during this period, the dose may be increased to 10 mg. When increasing the dose to 10 mg daily, administer with caution for gastrointestinal adverse reactions. When treatment with this medicine is discontinued, its effect gradually diminishes; no rebound effect occurs with abrupt discontinuation. ○ Female patients aged 85 years or older with low body weight: Careful monitoring is necessary because adverse reactions occur more frequently. Elderly women with low body weight should not exceed 5 mg daily.

Child dose

○ Children: There is no experience with use in children.

This medication contains the ingredient donepezil hydrochloride and is used for treating symptoms of Alzheimer’s type dementia. First, this medication should not be used by certain patients. For example, individuals with allergies to this medication or its ingredients, pregnant women or those who may become pregnant, nursing mothers, and those with lactose intolerance or certain genetic lactose-related disorders should not take this medication. Patients with heart disease, a history of peptic ulcers, asthma, or obstructive pulmonary diseases need to use this medication with special caution. This medication can slow down heart rate or induce arrhythmias, worsen symptoms of gastric ulcers, and may exacerbate asthma symptoms. Moreover, patients with extrapyramidal disorders such as Parkinson’s disease should be cautious as this medication may worsen their symptoms. This medicine contains the dye Tartrazine, and those allergic to this ingredient should also be careful. Various adverse reactions may occur during the use of this medication. Commonly reported symptoms include dizziness, nausea, vomiting, diarrhea, loss of appetite, insomnia, headache, and fatigue. In severe cases, syncope, heart problems, liver function abnormalities, cerebrovascular issues, muscle problems, respiratory distress, acute pancreatitis, acute renal failure, or sudden death may occur, so any symptoms should be promptly discussed with a doctor. This medication can affect the cardiovascular system, so patients with heart conditions may require regular electrocardiograms. Additionally, since this drug stimulates gastric acid secretion, it may worsen peptic ulcers, hence caution is advised for those with a history of gastrointestinal disorders. It may affect the ability to drive or operate machinery, so caution is advised during initial use or dose changes of this medication. Pregnant or nursing women are advised not to use this medication unless absolutely necessary and should consult a specialist before use. Safety in children has not been established, so it is not used in this population. This medication is metabolized in the liver, so patients with impaired liver function should exercise caution. In cases of overdose, serious symptoms may present, including nausea, vomiting, sweating, bradycardia, hypotension, respiratory depression, so immediate medical attention is required. Atropine may be used as an antidote. This medication may interact with other drugs, so especially when taken with heart-related drugs, antibiotics, antidepressants, antipsychotic drugs, or anti-inflammatory analgesics, consultation with a doctor or pharmacist is necessary. Finally, this medication should be stored out of reach of children, and it is safer not to transfer it to other containers.

• Syncope
• bradycardia
• heart block
• prolonged QT interval
• myocardial infarction
• heart failure
• peptic ulcer
• perforated duodenal ulcer
• gastrointestinal bleeding
• hepatitis

This medication should be stored in a tightly sealed container to prevent air from entering, and it is safe to keep it at room temperature between 1°C and 30°C. Storing it this way helps maintain the effectiveness of the medication.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle