Hypenocil OD Tablet 5 mg (Donepezil Hydrochloride Hydrate)

Adult dose

Administer 5 mg of Donepezil Hydrochloride once daily before bedtime. After administering the 5 mg dose for 4 to 6 weeks and after evaluating the clinical response, the dose can be increased to 10 mg. Care should be taken to monitor gastrointestinal side effects when increasing the dose to 10 mg. This medication is an orally disintegrating tablet that can be placed on the tongue and swallowed with water or without water.

Child dose

There is no experience using this medication in children.

This medication is used to treat symptoms of Alzheimer's type dementia, containing Donepezil Hydrochloride as the active ingredient. Firstly, this medication should not be used by individuals who are allergic to Donepezil Hydrochloride, piperidine derivatives, or any other component of this medication. Furthermore, pregnant women, women who may become pregnant, and nursing mothers should not take this medication. Patients with heart diseases, especially those with bradycardia or heart conduction disorders, should use this medication with caution, as it may cause heart problems such as bradycardia or arrhythmia. Patients taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcers should be cautious as increased gastric acid secretion and gastrointestinal motility may worsen symptoms. Patients with a history of asthma or obstructive pulmonary disease should also be cautious, as bronchoconstriction and increased mucus secretion may worsen symptoms. Patients with extrapyramidal disorders like Parkinson's disease may experience exacerbation of symptoms with this medication. This medication may cause various side effects, including severe instances like syncope, bradycardia, heart block, gastrointestinal bleeding, liver dysfunction, seizures, movement disorders, muscle anomalies, etc. Also, mild side effects may include nausea, vomiting, diarrhea, dizziness, insomnia, headache, and fatigue. This medication is not approved for use in other forms of dementia or memory disorders apart from Alzheimer's type dementia, and treatment should be conducted under the supervision of an experienced physician. During administration, the patient's condition and treatment effects should be evaluated regularly, and discontinuation should be considered if no effect is noted. In patients with heart disease, monitoring that includes ECG testing may be necessary, as this medication can affect heart rhythms. This medication is primarily metabolized in the liver, so caution is needed for patients with decreased liver function or liver-related diseases. Care must be taken as this medication may affect driving or machine operating abilities, especially during the initial period or when dosage is changed. This medication can interact with various drugs, especially those that inhibit or induce CYP3A4 and CYP2D6 enzymes; caution is required when using them together. Also, co-administration with drugs affecting heart conduction may increase the risk of side effects. Pregnant and nursing women should generally avoid this medication, and it should only be used when absolutely necessary and under specialist guidance. The safety in pediatric use has not been established, thus it should not be used in children. In cases of overdose, serious side effects such as nausea, vomiting, bradycardia, hypotension, and respiratory depression may occur, and immediate contact with a healthcare institution is necessary for appropriate treatment. This medication is in the form of an orally disintegrating tablet and should be dissolved in the mouth before swallowing with saliva or water.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in the mouth/eyes mucosa, shortness of breath or difficulty breathing, asthma attack, respiratory distress accompanied by cough + fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headache, lightning headache, seizures, confusion, visual disturbances, paralysis, urination

Mild side effects

• Diarrhea
• nausea
• vomiting
• decreased appetite
• headache
• fatigue
• fever
• dizziness
• insomnia
• drowsiness

This medication should be stored in a sealed container to prevent air ingress and should be kept at room temperature between 1 degree and 30 degrees Celsius. Doing so will help maintain the effectiveness of the medication for a longer period.

Appearance

White, round orally disintegrating tablet

Package unit

:30 tablets (10 tablets/ PTP packaging x 3)