Solica 10mg (Solifenacin succinate)

Adult dose

The usual recommended dose for adults (including the elderly) is 5mg once daily. If necessary, the dose may be increased to a maximum of 10mg once daily. This medicine may be taken with or without food and should be swallowed whole with water. Dosage adjustment is required for the following patients. 1. Patients with renal impairment No dosage adjustment is necessary in patients with mild or moderate renal impairment (creatinine clearance>30ml/min). In patients with severe renal impairment (creatinine clearance≤30ml/min), administer with caution and do not exceed 5mg once daily. 2. Patients with hepatic impairment No dosage adjustment is necessary in patients with mild hepatic impairment. In patients with moderate hepatic impairment (Child-Pugh class B), administer with caution and do not exceed 5mg once daily. 3. Patients receiving a strong cytochrome P450 3A4 (CYP3A4) inhibitor For patients receiving ketoconazole or another strong CYP3A4 inhibitor (e.g., ritonavir, nelfinavir, itraconazole), limit the maximum daily dose to 5mg.

This medication should not be used in patients with urinary retention or severe gastrointestinal diseases. It should also not be administered to patients with myasthenia gravis or angle-closure glaucoma, and those allergic to this drug or its components should avoid it. The use of this medication is prohibited in patients undergoing hemodialysis or those with severe liver or kidney dysfunction. Caution should be exercised when using this drug in patients with bladder outlet obstruction or reduced gastrointestinal motility. Patients with severe renal or hepatic impairment should have their dose reduced, and caution is advised when taking with strong CYP3A4 inhibitors such as certain antifungals. Common side effects of this medication may include dry mouth, constipation, blurred vision, urinary retention, dry eyes, peripheral edema, fatigue, cough, hypertension, nausea, dyspepsia, abdominal pain, vomiting, urinary tract infection, influenza, pharyngitis, dizziness, depression, urination difficulties, decreased urinary flow, post-void residual, cystitis, rhinitis, vomiting, gastroesophageal reflux disease, headache, hallucinations, drowsiness, delirium, renal impairment, itching, rash, angioedema, erythema multiforme, exfoliative dermatitis, atrial fibrillation, tachycardia. Serious adverse reactions such as anaphylaxis, angioedema, chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, severe rash with fever, blistering, skin peeling, mucosal pain, severe skin reactions, respiratory difficulties, asthma attacks, respiratory problems with cough and fever, jaundice (yellowing of skin or eyes), severe lethargy, liver problems (jaundice), sudden reactions should be closely monitored. Patients with QT prolongation syndrome or hyperkalemia should be cautious due to the risk of cardiac arrhythmias. If angioedema or anaphylactic reactions occur, administration should be stopped immediately, and appropriate treatment should be sought. This medication may enhance the effects or side effects when taken in combination with other anticholinergic drugs, so caution is needed when used together. Additionally, it may reduce the effectiveness of medications that promote gastrointestinal motility, so consultation with a healthcare provider is recommended. Safety has not been established for pregnant women; caution is required, and breastfeeding mothers should avoid using this product as it may be excreted in breast milk. Safety and efficacy in children have not been confirmed, so it should not be administered to pediatric patients. In case of overdose, inducing vomiting should be avoided, and appropriate emergency treatment such as administering activated charcoal is necessary. Specialized treatment may be required depending on the severity of symptoms. Caution is required when driving or operating machinery, as drowsiness or blurred vision may occur.

• Dry mouth
• constipation
• blurred vision
• urinary retention
• dry eyes
• fecal impaction
• colonic obstruction
• intestinal obstruction
• angioedema
• nausea

This medication should be stored in a tightly closed container to prevent air or moisture ingress. Additionally, it is recommended to store the drug at a cool and temperate room temperature between 1 to 30 degrees Celsius.

Appearance

Light pink round film-coated tablet

Package unit

100 tablets (10 tablets/PTP x 10)